Findings on Alzheimer Disease Reported by Researchers at Catholic University of Korea (Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study)

Disease Prevention Daily

2020 APR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Alzheimer Disease. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, “Although the pathogenesis of Alzheimer’s disease (AD) is unclear, neuroinflammation appears to play a role in its development. Psoriasis is a chronic inflammatory skin disease that has recently been found to genetically overlap with AD.”

Our news journalists obtained a quote from the research from the Catholic University of Korea, “We aimed to investigate the risk of AD in patients with psoriasis. Subjects with psoriasis (n=535,927) and age-and sex-matched controls without psoriasis (at a 5:1 ratio; n=2,679,635) who underwent 3 health examinations between 2008 and 2014 were included, drawn from the Korean National Health Insurance System database. There were 50,209 cases of AD (1.87%) in controls without psoriasis and 11,311 cases (2.11%) in patients with psoriasis, and the median follow-up was 3.35 years. In a multivariable-adjusted model, patients with psoriasis showed a significantly increased risk of AD (hazard ratio, 1.09; 95% CI, 1.07-1.12, p<0.0001) compared to controls without psoriasis. Among patients with psoriasis, the risk of AD was significantly increased in psoriasis patients not receiving systemic therapy compared to those receiving systemic therapy (hazard ratio, 1.10; 95% CI, 1.08-1.12 vs. hazard ratio, 0.99; 95% CI: 0.90-1.09, p<0.0001). The incidence of AD was significantly increased in patients with psoriasis compared to control subjects without psoriasis.”

According to the news editors, the research concluded: “Of note, systemic treatment for psoriasis was associated with a reduced risk of AD.”

For more information on this research see: Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study. Scientific Reports, 2020;10(1):6454. (Nature Publishing Group - http://www.nature.com/; Scientific Reports - http://www.nature.com/srep/)

Our news journalists report that additional information may be obtained by contacting H.E. Park, Dept. of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, Catholic University of Korea, #10, 63-ro, Yeongdeungpo-gu, 07345, Seoul, South Korea. Additional authors for this research include M. Kim, S.H. Lee, K. Han and J.H Lee.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41598-020-63550-2. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.