Findings from Ajou University Provide New Insights into Clinical Trials and Studies (Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on Clinical Research - Clinical Trials and Studies are presented in a new report. According to news reporting out of Suwon, South Korea, by NewsRx editors, research stated, "A diabetes risk score in Korean adults was developed and validated. This study used the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) of 359,349 people without diabetes at baseline to derive an equation for predicting the risk of developing diabetes, using Cox proportional hazards regression models."

Financial supporters for this research include Korea Health Industry Development Institute, National Health Insurance Service Ilsan Hospital (see also Clinical Research - Clinical Trials and Studies).

Our news journalists obtained a quote from the research from Ajou University, "External validation was conducted using data from the Korean Genome and Epidemiology Study. Calibration and discrimination analyses were performed separately for men and women in the development and validation datasets. During a median follow-up of 10.8 years, 37,678 cases (event rate=10.4 per 1,000 person-years) of diabetes were identified in the development cohort. The risk score included age, family history of diabetes, alcohol intake (only in men), smoking status, physical activity, use of antihypertensive therapy, use of statin therapy, body mass index, systolic blood pressure, total cholesterol, fasting glucose, and. glutamyl transferase (only in women). The C-statistics for the models for risk at 10 years were 0.71 (95% confidence interval [CI], 0.70 to 0.73) for the men and 0.76 (95% CI, 0.75 to 0.78) for the women in the development dataset. In the validation dataset, the C-statistics were 0.63 (95% CI, 0.53 to 0.73) for men and 0.66 (95% CI, 0.55 to 0.76) for women."

According to the news editors, the research concluded: "The Korean Diabetes Risk Score may identify people at high risk of developing diabetes and may be an effective tool for delaying or preventing the onset of condition as risk management strategies involving modifiable risk factors can be recommended to those identified as at high risk."

For more information on this research see: Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study. Diabetes & Metabolism Journal, 2018;42(5):402-414. Diabetes & Metabolism Journal can be contacted at: Korean Diabetes Assoc, 1010 Renaissance Tower Bldg, 14 Manrijae-Ro, Mapo-Guo, Seoul, 121-706, South Korea.

Our news journalists report that additional information may be obtained by contacting D.J. Kim, Ajou University, Cardiovasc & Metab Dis Etiol Res Center, Sch Med, Suwon, South Korea. Additional authors for this research include Y.H. Lee, S.O. Song, J.W. Lee, D.W. Kim, K.H. Cho and K.H. Ha.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.4093/dmj.2018.0014. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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