Study Findings from Okayama University Provide New Insights into Chronic Kidney Disease (The Beneficial Effect of Personalized Lifestyle Intervention in Chronic Kidney Disease Follow-Up Project for National Health Insurance Specific Health …): Kidney Diseases and Conditions – Chronic Kidney Disease

Health & Medicine Business Daily

2022 NOV 29 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Business Daily -- Research findings on chronic kidney disease are discussed in a new report. According to news originating from Okayama, Japan, by NewsRx correspondents, research stated, “* * Background and Objectives:* * Mimasaka city is a relatively small city with a population of 28,381, and an aging rate ( 65 years old) of 38.9%, where only one nephrology clinic is available. Since 2013, the city has conducted its own unique lifestyle intervention for the participants of the National Health Insurance specific medical health checkup, aiming to prevent the progression of chronic kidney disease (CKD) severity.”

Our news editors obtained a quote from the research from Okayama University: “* * Materials and Methods:* * The persons in National Health Insurance specific medical health checkup (40-74 years old) conducted in Mimasaka city in 2013, with eGFR less than 50 mL/min/1.73 m² or 50-90 mL/min/1.73 m² with urine dipstick protein 1+ or more, were registered for the CKD follow-up project, as high-risk subjects for advanced renal dysfunction. Municipal workers directly visited the subjects’ homes to provide individual health guidance and encourage medical consultation. We aimed to examine the effect of home-visit intervention on the changes of renal function and related factors until 2017. * * Results:* * The number of the high-risk subjects who continuously received the health checkup until 2017 was 63, and only 23 (36.5%) visited a medical institution in the first year. The eGFR decreased by only 0.4 mL/min/1.73 m²/year, and the subjects with urinary protein 1+ or higher decreased significantly from 20 (31.7%) to 9 (14.3%) (* * p* * = 0.034) in the high-risk subjects. The changes in eGFR and urinary protein was almost in the same fashion regardless of their medical institution visits. Next, we examined the effects of various factors on DeGFR, the changes of eGFR from 2013 to 2017, by multivariate linear regression analysis. The effects of medical institution visit were not significant, and the degree of urinary protein (coefficient B: 4.503, b: 0.705, * * p* * < 0.001), age (coefficient B: 4.753, b: 0.341, * * p* * = 0.004), and smoking (coefficient B: 5.878, b: 0.295, * * p* * = 0.031) had independent significant effects, indicating that they were the factors exacerbating the decrease in eGFR from the baseline.”

According to the news editors, the research concluded: “* * Conclusions:* * The personalized lifestyle intervention by home-visit in CKD follow-up project showed the possibility of beneficial effects on the deterioration of renal function. This may be an efficient method to change behavior in a small community with limited medical resources.”

For more information on this research see: The Beneficial Effect of Personalized Lifestyle Intervention in Chronic Kidney Disease Follow-Up Project for National Health Insurance Specific Health Checkup: A Five-Year Community-Based Cohort Study. Medicina, 2022,58(1529):1529. (Medicina - http://www.mdpi.com/journal/medicina). The publisher for Medicina is MDPI AG.

A free version of this journal article is available at https://doi.org/10.3390/medicina58111529.

Our news journalists report that additional information may be obtained by contacting Hidemi Takeuchi, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Additional authors for this research include Haruhito A. Uchida, Katsuyoshi Katayama, Natsumi Matsuoka-Uchiyama, Shugo Okamoto, Yasuhiro Onishi, Yuka Okuyama, Ryoko Umebayashi, Kodai Miyaji, Akiko Kai, Izumi Matsumoto, Keiko Taniguchi, Fukiko Yamashita, Tsutomu Emi, Hitoshi Sugiyama, Jun Wada.