Study Data from Sungkyunkwan University School of Medicine Provide New Insights into Clinical Trials and Studies (Recipient Age and Mortality After Liver Transplantation: A Population-based Cohort Study)

Clinical Trials Week

By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Clinical Research - Clinical Trials and Studies. According to news reporting from Seoul, South Korea, by NewsRx journalists, research stated, "The feasibility of liver transplantation (LT) in elderly recipients remains a topic of debate. This cohort study evaluated the impact of recipient's age on LT outcome between January 2007 and May 2016 covered by the Korean National Health Insurance system (n=9415)."

The news correspondents obtained a quote from the research from the Sungkyunkwan University School of Medicine, "Multilevel regression models were used to determine the impact of recipient's age on in-hospital and long-term mortality after LT. All patients had a first LT, with 2473 transplanted with liver from deceased donors (DD) and 6942 from living donors. The mean age was 52.2 ? 9.0 years. Most LT were performed on patients in their 50s (n=4290, 45.6%) and 0.9% (n=84) of the LT was performed on patients older 70 years. The overall in-hospital mortality was 6.3%, and the 3-year mortality was 11.3%. The in-hospital mortality included, 13.5% associated with DDLT and 3.7% involved living donor LT. When compared with that for patients aged 51 to 55 years, the risk of death among recipients older than 70 years was about fourfold higher after adjusting for baseline liver disease (odds ratio, 4.1; 95% confidence interval, 2.21-7.58), and was nearly threefold higher after adjusting for baseline liver disease and perioperative complications (odds ratio, 2.92; 95% confidence interval, 1.37-6.24). Also, the cost of LT increased significantly with age."

According to the news reporters, the research concluded: "The data show that age remains an important risk factor for LT, suggesting that LT should be considered with caution in elderly recipients."

For more information on this research see: Recipient Age and Mortality After Liver Transplantation: A Population-based Cohort Study. Transplantation, 2018;102(12):2025-2032. (Lippincott Williams and Wilkins - www.lww.com; Transplantation - journals.lww.com/transplantjournal/pages/default.aspx)

Our news journalists report that additional information may be obtained by contacting E. Gil, Dept. of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Additional authors for this research include J.M. Kim, K. Jeon, H. Park, D. Kang, J. Cho, G.Y. Suh and J. Park (see also Clinical Research - Clinical Trials and Studies).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1097/TP.0000000000002246. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.