Researchers from Ocean University of China Describe Findings in Managed Care (Genome Analysis and 2′-fucosyllactose Utilization Characteristics of a New akkermansia Muciniphila Strain Isolated From Mice Feces): Managed Care

2023 OCT 26 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Investigators publish new report on Managed Care. According to news reporting originating from Shandong, People’s Republic of China, by NewsRx correspondents, research stated, “Akkermansia muciniphila is considered to be a next-generation probiotic, and closely related to host metabolism and immune response. Compared with other probiotics, little is known about its genomic analysis.”

Financial supporters for this research include National Natural Science Foundation of China (NSFC), China Postdoctoral Science Foundation.

Our news editors obtained a quote from the research from the Ocean University of China, “Therefore, further researches about isolating more A. muciniphila strains and exploring functional genes are needed. In the present study, a new strain isolated from mice feces was identified as A. muciniphila (Muc(X)). Whole-genome sequencing and annotation revealed that Muc(X) possesses key genes necessary for human milk oligosaccharides (HMO) utilization, including alpha-L-fucosidases, beta-galactosidases, exo-alpha-sialidases, and beta-acetylhexosaminidases. The complete metabolic pathways for gamma-aminobutyric acid and squalene and genes encoding functional proteins, such as the outer membrane protein Amuc_1100, were annotated in the Muc(X) genome. Comparative genome analysis was used to identify functional genes unique to Muc(X) compared to six other A. muciniphila strains. Results showed Muc(X) genome possesses unique genes, including sugar transporters and transferases. Single-strain incubation revealed faster utilization of 2’-fucosyllactose (2’-FL), galacto-oligosaccharides, and lactose by Muc(X) than by A. muciniphila DSM 22959.”

According to the news editors, the research concluded: “This study isolated and identified an A. muciniphila strain that can utilize 2’-FL, and expolored the genes related to HMO utilization and special metabolites, which provided a theoretical basis for the further excavation of A. muciniphila function and the compound application with fucosylated oligosaccharides.”

This research has been peer-reviewed.

For more information on this research see: Genome Analysis and 2′-fucosyllactose Utilization Characteristics of a New akkermansia Muciniphila Strain Isolated From Mice Feces. Molecular Genetics and Genomics, 2022;297(6):1515-1528. Molecular Genetics and Genomics can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Molecular Genetics and Genomics - http://www.springerlink.com/content/1617-4615/)

The news editors report that additional information may be obtained by contacting Haijin Mou, Ocean University of China, College of Food Science and Engineering, Qingdao 266003, Shandong, People’s Republic of China. Additional authors for this research include Wei Gao, Mengshi Xiao, Ziqiang Gu, Xinmiao Ren, Ying Yu, Zhemin Liu, Changliang Zhu, Qing Kong and Xiaodan Fu.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s00438-022-01937-8. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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