Researchers from Asia University Detail New Studies and Findings in the Area of Cholelithiasis (The association between bowel obstruction and the management of cholelithiasis and cholecystitis in elderly patients: A population-based cohort study)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Digestive System Diseases and Conditions - Cholelithiasis have been published. According to news originating from Taichung, Taiwan, by NewsRx correspondents, research stated, "This study aimed to evaluate the risk of bowel events among elderly patients treated using only PTGBD (Percutaneous Gallbladder Drainage), or a cholecystectomy on its own, or PTGBD combined with a subsequent cholecystectomy. A retrospective population-based cohort study was conducted with newly diagnosed cholelithiasis and cholecystitis patients who had no bowel obstruction history and were aged over 65 years during the period of January 1, 2000 to December 31, 2010."

Funders for this research include Ministry of Health and Welfare, China Medical University Hospital, Academia Sinica, MOST Clinical Trial Consortium (see also Digestive System Diseases and Conditions - Cholelithiasis).

Our news journalists obtained a quote from the research from Asia University, "These patients were placed into 3 separate study cohorts; PTGBD alone, cholecystectomy alone and PTGBD with subsequent laparoscopic cholecystectomy, with the cohort frequencies matched by age and gender. We defined the index date as the time of the initial cholelithiasis and cholecystitis diagnosis date and began observation and suspended follow-up when the patient had either withdrawn from their health insurance, developed bowel obstruction or reached the date of December 31, 2011. The incidences of bowel obstruction were 24.6, 19.2 and 13.6 per 1000 person-years for PTGBD cohort, cholecystectomy cohort and PTGBD respectively, with a subsequent laparoscopic cholecystectomy cohort. Compared with the PTGBD cohort, (which was adjusted for age, gender, CCI score and laparotomy history), the hazard ratio of bowel obstruction was 0.77 (95% Confidence Interval (CI) = 0.59-1.00) and 0.57 (95% CI = 0.43-0.76) for the cholecystectomy cohort and PTGBD with a subsequent laparoscopic cholecystectomy cohort respectively."

According to the news editors, the research concluded: "For treatment of cholelithiasis and cholecystitis in elderly patients, PTGBD with a subsequent cholecystectomy could benefit patients by providing a lower risk of ileus or intestinal obstruction."

For more information on this research see: The association between bowel obstruction and the management of cholelithiasis and cholecystitis in elderly patients: A population-based cohort study. European Journal of Internal Medicine, 2018;57():83-90. European Journal of Internal Medicine can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Internal Medicine - www.journals.elsevier.com/european-journal-of-internal-medicine/)

The news correspondents report that additional information may be obtained from C.H. Kao, Asia Univ, Dept. of Bioinformat & Med Engn, Taichung, Taiwan. Additional authors for this research include C.L. Lin, H.Z. Yeh, C.S. Chang and Y.C. Peng.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ejim.2018.07.005. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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