Researcher from National Health Insurance Service Ilsan Hospital Reports on Findings in Obstructive Sleep Apnea (Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea): Respiratory Tract Diseases and Conditions – Obstructive Sleep Apnea

2023 AUG 21 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Diabetes Daily -- New research on obstructive sleep apnea is the subject of a new report. According to news originating from Goyang, South Korea, by NewsRx correspondents, research stated, “The results of previous studies on sex differences in mortality and comorbidities among patients with acromegaly are diverse. We assessed the sex differences in mortality and the risk of complications in patients with acromegaly.”

Our news editors obtained a quote from the research from National Health Insurance Service Ilsan Hospital: “We included 1884 patients with acromegaly with 1:50 age- and sex-matched 94200 controls using the Korean nationwide claims database from 2009 to 2019. During the median 5.51 years of follow-up, the acromegaly group had higher all-cause mortality than the control group (hazard ratio [HR] 1.74, 95% CI 1.38-2.19), with higher risk in women than men (HR 2.17 vs. 1.36). The most common cause of death was malignancy. Women with acromegaly aged 50 years exhibited significantly higher mortality than men with acromegaly aged 50 years (HR 1.74 vs. 0.96). In a treatment subgroup other than surgery alone, women had a higher risk of mortality than men (HR 2.82 vs. 1.58). Sex differences in mortality among patients with acromegaly remained equal after adjustment for the Charlson Comorbidity Index, socioeconomic status, body mass index, alcohol consumption, smoking, fasting plasma glucose, creatinine, and total cholesterol. Patients with acromegaly had elevated risks of developing major adverse cardiovascular events, atrial fibrillation, obstructive sleep apnea (OSA), diabetes mellitus (DM), end-stage renal disease, Parkinson’s disease, depression, and malignancy than age- and sex-matched controls, with a higher risk of OSA and DM in women than men.”

According to the news editors, the research concluded: “The risk of mortality and complication in patients with acromegaly compared to age- and sex-matched controls were higher in women than in men.”

For more information on this research see: Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea. European Journal of Endocrinology, 2023. The publisher for European Journal of Endocrinology is Oxford University Press (OUP).

A free version of this journal article is available at https://doi.org/10.1093/ejendo/lvad106.

Our news journalists report that additional information may be obtained by contacting Jiwon Kim, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, South Korea. Additional authors for this research include Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Jae Won Hong, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku.

ORCID is an identifier for authors and includes bibliographic information. The following is ORCID information for the authors of this research: Namki Hong (http://orcid.org/0000-0002-8246-1956), Eun Jig Lee (http://orcid.org/0000-0002-9876-8370), Sin Gon Kim (http://orcid.org/0000-0002-7430-3675), Cheol Ryong Ku (http://orcid.org/0000-0001-8693-9630).

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