New Findings from Seoul National University in Alzheimer Disease Provides New Insights (Association of Anticholinergic Use With Incidence of Alzheimer’s Disease: Population-based Cohort Study)

Disease Prevention Daily

2019 JUN 13 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Fresh data on Neurodegenerative Diseases and Conditions - Alzheimer Disease are presented in a new report. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, “Drugs with strong anticholinergic properties are used under a variety of conditions; however, they can cause various adverse effects including a negative impact on cognitive functions, with older adults being more susceptible to these effects. We explored whether the use of anticholinergic agents (ACs) affects the risk of Alzheimer’s disease (AD) in terms of incidence by using National Health Insurance Service elderly cohort database (2002-2013).”

Our news editors obtained a quote from the research from Seoul National University, “As a result, AD risk was higher in subjects with an increased amount of prescriptions for strong ACs over a long period of time (9-12 years) than that in the leastexposed reference group (0-9 dose/year) [hazard ratio (HR) (95% confidence interval (95% CI)) 0.99 (0.95-1.03), 1.19 (1.12-1.26), 1.39 (1.30-1.50); in the 10-49 doses/year, 50-119 doses/year, and >= 120 doses/year groups]. Hazard ratios were particularly high in the young-old subgroup (60-64 years old in 2002) [HR (95%CI) 1.11 (1.04-1.22), 1.43 (1.25-1.65), 1.83 (1.56-2.14); in the 10-49 doses/year, 50-119 doses/year, and >= 120 doses/year groups].”

According to the news editors, the research concluded: “Use of strong ACs dose-dependently increased the risk of AD in terms of incidence when exposure was followed up for 9 years or more, and the association was greater in the young-old subgroup.”

For more information on this research see: Association of Anticholinergic Use With Incidence of Alzheimer’s Disease: Population-based Cohort Study. SCIENTIFIC REPORTS, 2019;9():. SCIENTIFIC REPORTS can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - http://www.nature.com/; SCIENTIFIC REPORTS - http://www.nature.com/srep/)

The news editors report that additional information may be obtained by contacting S.I. Cho, Seoul National University, Graduate School of Public Health, Dept. of Public Health Sciences, Seoul 08826, South Korea. Additional authors for this research include K.I. Joung, S. Kim and Y.H. Cho.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41598-019-43066-0. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.