China Medical University and Hospital Reports Findings in Vascular Diseases and Conditions (Risk Factors of Dementia in Patients with Cerebral Vascular Diseases Based on Taiwan National Health Insurance Data): Cardiovascular Diseases and Conditions – Vascular Diseases and Conditions

2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Business Daily -- New research on Cardiovascular Diseases and Conditions - Vascular Diseases and Conditions is the subject of a report. According to news reporting originating in Taichung, Taiwan, by NewsRx journalists, research stated, “Vascular factors have been shown to be associated with increased risk of dementia. However, clinical trials have so far been unsuccessful, suggesting new approaches are needed.”

The news reporters obtained a quote from the research from China Medical University and Hospital, “The aim of this study was to use population-based real-world data to investigate risk factors and preventive factors for dementia, including the effects of traditional Chinese medicine (TCM). This is a retrospective cohort study using LHID2000, a dataset randomly selected from Taiwan’s National Health Insurance Research Database. Subjects with occlusion and stenosis of precerebral and cerebral arteries, cerebral atherosclerosis without mention of cerebral infarction, and transient cerebral ischemia were included. Subjects with dementia at baseline were excluded. The primary endpoint was dementia. Data for demographic and clinical comorbid status and treatments administered at baseline in 2000 and at the end of follow-up in 2013 were included. A total of 4,207 subjects with cerebral vascular disease and no cognitive impairment were included, of whom 392 converted to dementia during an average 5.15-year (SD: 3.79) follow-up. Depression (adjusted HR: 1.54, 95% confidence interval [CI]: 1.13-2.09), osteoporosis (adjusted HR: 1.34, 95% CI: 1.04-1.74), and the use of enalapril (adjusted HR: 1.37, 95% CI: 1.09-1.73) were risk factors for dementia, while nitroglycerin (adjusted HR: 0.67, 95% CI: 0.53-0.85) was a protecting factor, in subjects with cerebrovascular diseases without mention of cerebral infarction. In total, statins were shown to be associated with decreased risk of dementia (HR: 0.73, 95% CI: 0.59-0.91); however, no one statin subtype or TCM had such an effect.”

According to the news reporters, the research concluded: “Depression, osteoporosis, and the use of enalapril were associated with a higher risk of dementia, while nitroglycerin might be a protecting factor for dementia, in subjects with cerebrovascular diseases without mention of cerebral infarction.”

This research has been peer-reviewed.

For more information on this research see: Risk Factors of Dementia in Patients with Cerebral Vascular Diseases Based on Taiwan National Health Insurance Data. Dementia and Geriatric Cognitive Disorders, 2023;52(3):184-192. Dementia and Geriatric Cognitive Disorders can be contacted at: Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland. (Karger - http://www.karger.com/; Dementia and Geriatric Cognitive Disorders - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224226)

Our news correspondents report that additional information may be obtained by contacting Cheng-Li Lin, Clinical Trial Center (CTC), China Medical University and Hospital, Taichung, Taiwan. Additional authors for this research include Bin Zhou, Shinsuke Kojima, Masanori Fukushima and Chung Y. Hsu.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1159/000530102. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher of the journal Dementia and Geriatric Cognitive Disorders can be contacted at: Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland.

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