TrumpRx is here. What you should know

TrumpRx, a U.S. government–backed prescription drug discount platform, launched Thursday night with 43 prescription drugs listed as part of the program to help Americans pay lower cash prices for certain brand-name medications.

TrumpRx is aimed at those who are uninsured or who have high-deductible health plans. The website does not sell or prescribe drugs. It acts as a central location that shows discounted prices negotiated with drug manufacturers. The site gives users the option of downloading or printing coupons to redeem at a participating pharmacy or being redirected to the manufacturer’s own direct-to-consumer site to make the purchase.

Here’s how it works:

• Search for a medication by name on gov.
• If the drug is listed on the website, the user can either receive a coupon to use at a participating pharmacy or the user is sent to the drugmaker’s online pharmacy.
• TrumpRx does not take insurance. Users pay cash for the drugs.
• For users who have insurance, the purchase on TrumpRx typically does not count toward health plan out-of-pocket maximums or deductibles.

Medicare beneficiaries may access certain manufacturer-sponsored cash-pay drug programs (including those surfaced through TrumpRx) without triggering Anti‑Kickback risk—but only when the transaction is structured as a true cash purchase that is completely outside Medicare and meets strict safeguards. The guidance does not create a safe harbor and does not broadly authorize all discount programs.

The majority of drugs listed on TrumpRx come from five pharmaceutical companies: AstraZeneca, Eli Lilly, EMD Serono, Novo Nordisk and Pfizer. Drugs listed in the launch of TrumpRx include weight loss and diabetes drugs such as Wegovy, Ozempic and Zepbound; insulin, asthma and COPD inhalers, and IVF and fertility medications.

In announcing TrumpRx, President Donald Trump said additional medications are expected to be added to the website in the future.

What about the discounts?

Discounts on drugs listed on TrumpRx vary widely, but range from 33% to 90% off list prices. In particular, some weight loss drugs show prices discounted from more than $1,300 per month to anywhere between $149 and $349 monthly. IVF medications show discounts of thousands of dollars per treatment cycle. However, these discounts are usually compared with manufacturer list prices, which are often higher than what insurers usually pay.

Those who would benefit most from TrumpRx include uninsured consumers, people with high-deductible health plans, and patients whose medications are not covered by insurance.

People who are insured often pay less for their prescription drugs using their normal copays than they would by paying cash through TrumpRx. In fact, the website advises users to check their insurance cost first.

TrumpRx does not replace insurance, does not cover generic drugs, does not guarantee savings for everyone and does not automatically apply at every pharmacy.

TrumpRx is part of a broader effort to lower U.S. drug prices using a “most‑favored‑nation” pricing model, which ties U.S. prices to what other wealthy countries pay.

Where can TrumpRx coupons be redeemed?

GoodRx is a partner for the launch of TrumpRx, and many coupons work at the same major chains that already accept GoodRx discounts. Reported and commonly participating pharmacies include CVS, Walgreens, Walmart, Kroger, Albertsons, Costco and many independent local pharmacies.

Some TrumpRx medications must be obtained through manufacturer‑designated specialty pharmacies or direct‑to‑consumer mail‑order services. In those cases, TrumpRx sends consumers directly to the correct pharmacy during checkout.

After searching the website for a particular drug and clicking “Get coupon,” the website will show which pharmacies accept that coupon or a manufacturer website is pharmacy pickup isn’t available. Consumers must bring the downloaded or printed coupon to the pharmacy.

How does it compare with other payment methods?

The TrumpRx website advises users to check with their insurance to determine whether they will pay less out of pocket by using their coverage. How does TrumpRx compare with insurance GoodRx and Mark Cuban’s Cost Plus Drugs in what users will pay? Here is a chart.

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Susan Rupe is editor in chief, magazine, for InsuranceNewsNet. She formerly served as communications director for an insurance agents' association and was an award-winning newspaper reporter and editor. Contact her at susan.rupe@innfeedback.com.