The epidemiology and direct medical costs of diseases associated with human papillomavirus infection among men in Manitoba, Canada

2020 DEC 22 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Daily -- According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from medrxiv.org:

“Background: There is little information on the economic burden of human papillomavirus-related diseases (HPV-RDs) among men.

“We used province-wide clinical, administrative and accounting databases to measure the direct medical costs of HPV infections in men in Manitoba (Canada). Methods: We included all males aged 9 years and older with health insurance coverage in Manitoba between January 1997 and December 2016.

“We identified HPV-RD patient cohorts and matched each patient to HPV-RD-free men.

“We estimated the net direct medical cost (excess cost of hospitalizations, outpatient visits, and prescription drugs) of patients compared to their matches for anogenital warts (AGWs) and HPV-caused cancers.

“We adjusted costs to 2017 Canadian dollars. For each condition, we attributed costs to HPV based on the etiological fraction caused by HPV infection.

“Results: We found that the median net direct medical cost was about $250 for AGW patients and $16,000 for invasive cancer patients. The total cost was about $49 million or $2.6 million per year. Overall, 54%-67% ($26-$33 million) was attributable to HPV infection according different estimates of the attributable fraction. The net annual attributable cost was $2.37-$2.95 per male resident and $161-$200 per male newborn. The estimated potential savings was 30% for the bivalent vaccine and 56%-60% for the quadrivalent and nonavalent vaccines.

“Conclusions: Overall, HPV9s economic burden on males remains significant, the average cost of treating all conditions attributable to HPV was about $180 per male newborn. Invasive cancer accounted for the majority of these costs.”

This preprint has not been peer-reviewed.

For more information on this research see: http://medrxiv.org/content/10.1101/2020.12.02.20242891v1

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