Researchers at Tri-Service General Hospital Release New Study Findings on Dementia (Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study)

Disease Prevention Daily

2020 NOV 24 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- New study results on dementia have been published. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, “Results of studies regarding the potential link between acid suppressant use and dementia risk are inconsistent. This study aimed to evaluate the association of cumulative exposure to histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with dementia risk in an Asian older cohort aged 65 years.”

The news correspondents obtained a quote from the research from Tri-Service General Hospital: “Patients initiating H2RA (the H2RA user cohort, * * n* * = 21,449) or PPI (the PPI user cohort, * * n* * = 6584) and those without prescription for H2RA (the H2RA non-user cohort, * * n* * = 21,449) or PPI (the PPI non-user cohort, * * n* * = 6584) between 1 January 2000 and 31 December 2005 without a prior history of dementia were identified from Taiwan’s National Health Insurance Research Database (NHIRD). The outcome of interest was all-cause dementia. Patients’ exposure to H2RAs or PPIs was followed-up from dates of initial prescription to the earliest outcome of incident dementia, death, or the end of 2013. Potential associations between acid suppressant use and dementia risk were analyzed using time-dependent Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs). After mutual adjustment for H2RA and PPI use and other potential confounders, patients with H2RA use had significantly higher risk of developing dementia as compared to those not treated with H2RAs (adjusted HR, 1.84; 95% CI, 1.49-2.20). Likewise, PPI users had significantly elevated risk of dementia compared to PPI non-users (adjusted HR, 1.42; 95% CI, 1.07-1.84).”

According to the news reporters, the research concluded: “Our results indicate that exposures to H2RAs and PPIs are associated with increased dementia risk.”

For more information on this research see: Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study. International Journal of Environmental Research and Public Health, 2020,17(8271):8271. (International Journal of Environmental Research and Public Health - http://www.mdpi.com/journal/ijerph). The publisher for International Journal of Environmental Research and Public Health is MDPI AG.

A free version of this journal article is available at https://doi.org/10.3390/ijerph17218271.

Our news editors report that more information may be obtained by contacting Liang-Yu Chen, Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei City 114, Taiwan. Additional authors for this research include Huey-Juan Lin, Wen-Tung Wu, Yong-Chen Chen, Cheng-Li Chen, Jing Kao, San-Lin You, Yu-Ching Chou, Chien-An Sun.