Researcher at National Health Insurance Service Ilsan Hospital Targets Pheochromocytoma (Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma): Pheochromocytoma

2023 JUL 25 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Researchers detail new data in pheochromocytoma. According to news originating from Goyang, South Korea, by NewsRx correspondents, research stated, “We delved into the expression of amine oxidase family proteins and their potential significance in adrenal gland neoplasm.”

Our news journalists obtained a quote from the research from National Health Insurance Service Ilsan Hospital: “Tissue microarrays were prepared for 132 cases of adrenal cortical neoplasm (ACN) consisting of 115 cases of adrenal cortical adenoma (ACA), 17 cases of adrenal cortical carcinoma (ACC), and 163 cases of pheochromocytoma (PCC). Immunohistochemical stainings for MAOA, MAOB, LOX, and AOC3 were performed to evaluate the H-scores and compare them with clinicopathological parameters. The H-scores of MAOA (T; p = 0.005) and MAOB (T; p = 0.006) in tumor cells (T) were high in ACN, whereas LOX (T, S; p < 0.001) in tumor and stromal cells (S) and AOC3 (T; p < 0.001) were higher in PCC. In stromal cells, MAOA (S; p < 0.001) and AOC3 (S; p = 0.010) were more expressed in ACA than in ACC. MAOB (S) in PCC showed higher H-scores when the grading of adrenal pheochromocytoma and paraganglioma (GAPP) score was 3 or higher (p = 0.027).”

According to the news reporters, the research concluded: “In the univariate analysis, low MAOA expression in stromal cells of ACN was associated with shorter overall survival (p = 0.008). In conclusion, monoamine oxidase proteins revealed differences in expression between ACN and PCC and also between benign and malignant cells.”

For more information on this research see: Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma. Biomedicines, 2023,11(7). (Biomedicines - http://www.mdpi.com/journal/biomedicines). The publisher for Biomedicines is MDPI AG.

A free version of this journal article is available at https://doi.org/10.3390/biomedicines11071896.

Our news editors report that additional information may be obtained by contacting Eun Kyung Kim, Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyang 10444, South Korea. Additional authors for this research include Ja Seung Koo.

ORCID is an identifier for authors and includes bibliographic information. The following is ORCID information for the authors of this research: Eun Kyung Kim (http://orcid.org/0000-0002-9439-0446), Ja Seung Koo (http://orcid.org/0000-0003-4546-4709).

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