Research Results from University of Chicago Update Understanding of Prostate Cancer (Rising active surveillance rates/observation and regimen intensification in young men: A retrospective cohort study of national commercial health insurance …): Oncology – Prostate Cancer

2026 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Researchers detail new data in Oncology - Prostate Cancer. According to news reporting originating in Chicago, Illinois, by NewsRx journalists, research stated, “To analyze active surveillance/observation (AS/O) trends, treatment selection, treatment-free survival, and surveillance regimen intensity in men <65 using a national commercial health insurance claims database. We retrospectively reviewed the Merative Marketscan® Commercial Database for localized prostate cancer among men <65 years between 2004-2023.”

The news reporters obtained a quote from the research from the University of Chicago, “Each had a newly-diagnosed prostate cancer, a biopsy <180 days before diagnosis, and >2 evaluation and management visits for prostate cancer. The primary outcomes were treatment selection and health services claims after diagnosis. Descriptive statistics and Kaplan-Meier analyses are reported. We identified 29,484 men <65 years with localized prostate cancer, with median age 58.0 years (IQR 55.0-61.0). AS/O increased from 10.4% to 35.1%, while prostatectomy decreased from 55.5% to 42.8%. Overall, 5,861 (19.9%) men underwent AS/O in the first year after diagnosis; 4,561 (77.8%) remained on AS/O. After one year of AS/O, treatment-free survival rates at 2-, 3-, and 5- years were 86.1% (95%CI:85.1%-87.0%), 79.0% (77.8%-80.2%), and 68.8% (67.1%-70.4%), respectively. In the first two years of AS/O, men who had a urologist visit rose from 88.5% to 91.1%, biopsy from 18.0% to 48.9%, MRI from 0.0% to 63.7%, and PSA from 59.0% to 97.0%. Younger men have increased adoption of AS/O and intensified AS/O regimens over time.”

According to the news reporters, the research concluded: “These shifting treatment patterns could be due to improved guideline implementation or acceptance of AS/O to preserve functional status.”

This research has been peer-reviewed.

For more information on this research see: Rising active surveillance rates/observation and regimen intensification in young men: A retrospective cohort study of national commercial health insurance claims data. Urology, 2026. Urology can be contacted at: Elsevier Science Inc, Ste 800, 230 Park Ave, New York, NY 10169, USA. (Elsevier - www.elsevier.com; Urology - http://www.journals.elsevier.com/urology/)

Our news correspondents report that additional information may be obtained by contacting J. Bradley Mason, Surgical Implementation and Health Services Research, Dept. of Surgery, Section of Urology, University of Chicago, Chicago, Illinois, United States. Additional authors for this research include Max J. Hyman, Abhinav Sidana, Ted A. Skolarus and Parth K. Modi.

The publisher of the journal Urology can be contacted at: Elsevier Science Inc, Ste 800, 230 Park Ave, New York, NY 10169, USA.

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