Research Reports from National Health Insurance Service Ilsan Hospital Provide New Insights into Clinical Research (Risk of incident chronic kidney disease among patients with urolithiasis: a nationwide longitudinal cohort study): Clinical Research

Clinical Trials Daily

2024 MAR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Daily -- Fresh data on clinical research are presented in a new report. According to news reporting out of Gyeonggi Do, South Korea, by NewsRx editors, research stated, “Urolithiasis has been infrequently implicated to have a causal association with chronic kidney disease (CKD). Recently, several studies have demonstrated the relationship between urolithiasis and CKD.”

Our news reporters obtained a quote from the research from National Health Insurance Service Ilsan Hospital: “However, the generalizability of their results is limited. This study aimed to investigate the association between urolithiasis and the risk of incident CKD. This longitudinal cohort study used the National Health Insurance Service data, including 219 570 Korean adults with incident urolithiasis requiring procedural interventions and without prior kidney disease and 219 570 age- and sex-matched controls without urolithiasis between January 1, 2002, and December 31, 2020. Primary outcome was the development of CKD, defined by estimated glomerular filtration rate <60 mL/min/1.73 m2 for at least two consecutive measurements at least 90 days apart. Risk for the incident CKD was further examined using the outcome defined by newly occurring diagnostic codes indicating CKD. Over a mean follow-up of 6 years, 12 338 (2.8%) primary outcome events of CKD were observed (incidence rate, 4.6 per 1 000 person-years). Per multivariable Cox analysis, urolithiasis was associated with a higher risk of incident CKD (adjusted hazard ratio, 1.41; 95% confidence interval, 1.36-1.46). This association remained consistent across all clinically relevant subgroups and when the CKD outcome was defined based on the diagnostic codes in the sensitivity analysis.”

According to the news editors, the research concluded: “In this large national cohort study, patients with urolithiasis were associated with higher risk of incident CKD than those without urolithiasis. Further studies are warranted to establish the benefits of preventing urolithiasis in reducing CKD development.”

For more information on this research see: Risk of incident chronic kidney disease among patients with urolithiasis: a nationwide longitudinal cohort study. Clinical Kidney Journal, 2024. The publisher for Clinical Kidney Journal is Oxford University Press (OUP).

A free version of this journal article is available at https://doi.org/10.1093/ckj/sfae030.

Our news journalists report that more information may be obtained by contacting Jae Young Kim, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, South Korea. Additional authors for this research include Jae Kwang Lee, Jung Tak Park, Tae Ik Chang.

ORCID is an identifier for authors and includes bibliographic information. The following is ORCID information for the authors of this research: Jung Tak Park (http://orcid.org/0000-0002-2325-8982), Tae Ik Chang (http://orcid.org/0000-0003-3311-6379).