Research from University of Tokyo Yields New Findings on Dengue Hemorrhagic Fever (Clinical Management of Patients with Dengue Infection in Japan: Results from National Database of Health Insurance Claims)

2019 NOV 27 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Data detailed on Mosquito-Borne Diseases - Dengue Hemorrhagic Fever have been presented. According to news reporting originating in Tokyo, Japan, by NewsRx journalists, research stated, “Dengue guidelines for diagnosis, treatment, prevention, and control (WHO, 2011) recommend acetaminophen and isotonic fluid for patients with dengue infection but do not recommend nonsteroidal anti-inflammatory drugs (NSAIDs) and hypotonic fluid. Other research showed no evidence of efficacy of platelet infusion in prophylactic.”

The news reporters obtained a quote from the research from the University of Tokyo, “This research aims to clarify to what extent dengue patients were managed in accordance with the guidelines in Japan. We extracted claim data of patients with either dengue fever (DF) or dengue hemorrhagic fever (DHF) from the National Database of Health Insurance Claims and Specific Health Checkups of Japan between 2011 and 2015. The total number of patients was 1,370, which consisted of 1,306 DF patients and 64 DHF patients; 185 patients were younger than (<) 20 years and 1,185 patients were aged 20 years or older (). Among them, 24.5% of DF patients and 48.4% of DHF patients received hypotonic intravenous fluid, 12.9% and 18.8% NSAIDs, and 1.3% and 17.2% platelet transfusion, respectively. Comparing patients aged <20 years with patients aged 20 years, 57.8% and 54.5% received acetaminophen, 6.5% and 14.3% received NSAIDs, 40.0% and 38.3% received isotonic fluid, and 37.8% and 23.7% received hypotonic fluid, respectively. Platelet transfusion was used for 1.3% of DH and 17.2% of DHF patients. The study indicated that dengue patients in Japan might have increased risks of developing adverse events because of receiving the treatment that the guidelines do not recommend.”

According to the news reporters, the research concluded: “More effort is needed to facilitate medical practitioners to follow the guidelines.”

For more information on this research see: Clinical Management of Patients with Dengue Infection in Japan: Results from National Database of Health Insurance Claims. The American Journal of Tropical Medicine and Hygiene, 2019;():. The American Journal of Tropical Medicine and Hygiene can be contacted at: Amer Soc Trop Med & Hygiene, 8000 Westpark Dr, Ste 130, Mclean, VA 22101, USA.

Our news correspondents report that additional information may be obtained by contacting Y. Kajimoto, Graduate School of Pharmaceutical Science, University of Tokyo, Tokyo, Japan.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.4269/ajtmh.19-0070. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher of the The American Journal of Tropical Medicine and Hygiene can be contacted at: Amer Soc Trop Med & Hygiene, 8000 Westpark Dr, Ste 130, Mclean, VA 22101, USA.

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