Reports Outline Geriatrics and Gerontology Study Results from University of Pennsylvania Perelman School of Medicine (Frequency of and risk factors for potentially inappropriate medication use in Parkinson’s disease)

2020 APR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Investigators publish new report on Aging Research - Geriatrics and Gerontology. According to news reporting from Philadelphia, Pennsylvania, by NewsRx journalists, research stated, “impairments in neurotransmitter pathways put Parkinson’s disease (PD) patients at risk for drug-disease interactions and adverse medication events. to determine the prevalence and risk factors for potentially inappropriate medication (PIM) prescriptions, as defined by the 2015 Beers List, in PD.”

Funders for this research include National Institutes of Health, National Institute of Neurological Diseases and Stroke.

The news correspondents obtained a quote from the research from the University of Pennsylvania Perelman School of Medicine, “cross-sectional analysis was conducted on 2014 Medicare beneficiaries with PD who had parts A, B and D coverage. The prevalence of PIM prescriptions for older adults was determined overall, and specifically for medications that can exacerbate motor symptoms or cognitive impairment in PD. Logistic regression models were constructed to determine the association between age, sex, race, geography and poverty with PIM prescriptions. the final sample included 458,086 beneficiaries. In 2014, 35.8% of beneficiaries with PD filled a prescription for at least one PIM for older adults. In total, 8.7% of beneficiaries received a PIM that could exacerbate motor symptoms and 29.0% received a PIM that could worsen cognitive impairment. After adjustment, in all models, beneficiaries who were younger, female, white, urban-dwelling and eligible for Medicaid benefits were more likely to receive a PIM. PIM prescriptions are not uncommon in PD, particularly for medications that can exacerbate cognitive impairment. Future research will examine underlying drivers of sex and other disparities in PIM prescribing.”

According to the news reporters, the research concluded: “Additional studies are needed to understand the impact of PIMs on disease symptoms, healthcare utilisation and patient outcomes.”

For more information on this research see: Frequency of and risk factors for potentially inappropriate medication use in Parkinson’s disease. Age and Ageing, 2020;():. Age and Ageing can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - http://www.oup.com/; Age and Ageing - ageing.oxfordjournals.org)

Our news journalists report that additional information may be obtained by contacting T.P. Pham Nguyen, Dept. of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States. Additional authors for this research include D.S. Abraham, S. Hennessy, D. Weintraub, S.L. Gray, D. Xie and A.W Willis.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1093/ageing/afaa033. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Age and Ageing is: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England.

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