Reports from University of California Davis Describe Recent Advances in Cancer (Non-private Health Insurance Predicts Advanced Stage At Presentation and Amputation In Lower Extremity High Grade Bone Sarcoma: a National Cancer Database Study …): Cancer

2022 APR 15 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Investigators publish new report on Cancer. According to news reporting from Sacramento, California, by NewsRx journalists, research stated, “Advances in diagnostic and treatment modalities for high grade bone sarcomas (HGBS) of lower extremity (LE) have enabled limb salvage resections as a feasible first-line surgical option. However, amputations are still performed.”

The news correspondents obtained a quote from the research from the University of California Davis, “Impact of amputation on survival and predictive factors for amputation and the stage at presentation for HGBS of LE remain unknown. National Cancer Database was used to extract 5781 cases of high-grade bone sarcoma of the LE from 2004 to 2017. Kaplan-Meier and Cox regression were used to determine the impact of amputation on survival. Chi square test and logistic regression were used to assess the correlation of predictive factors with amputation and stage at presentation. Amputation [hazard ratio (HR) 1.516; 95% confidence interval (CI) 1.259-1.826; p< 0.001] and advanced stage (HR 0.248; 95% CI 0.176-0.351; p< 0.001) were independent predictors of poor overall survival. The impact of amputation on survival was most pronounced for pediatric and adolescents and young adults (AYA) age groups (18% decrease in 10-year survival). Amputation was more likely to be performed among those with nonprivate insurance (HR 1.736; 95% CI 1.191-2.531; p = 0.004), a finding that was mirrored for advanced stage at presentation (HR 0.611; 95% CI 0.414-0.902; p = 0.013). Amputation is an independent predictor of poor outcomes among patients with HGBS of LE. The impact of amputation on survival is the highest for the pediatric and AYA age group. Nonprivate insurance is associated with increased likelihood of amputation and an advanced stage at presentation among patients with high-grade bone sarcoma of the LE.”

According to the news reporters, the research concluded: “This is the largest study highlighting insurance-related disparities in this cohort.”

This research has been peer-reviewed.

For more information on this research see: Non-private Health Insurance Predicts Advanced Stage At Presentation and Amputation In Lower Extremity High Grade Bone Sarcoma: a National Cancer Database Study Amputation Predicts Survival: an Effect Most Pronounced In Pediatric and Aya Age Group. Annals of Surgical Oncology, 2022. Annals of Surgical Oncology can be contacted at: Springer, One New York Plaza, Suite 4600, New York, Ny, United States. (Springer - www.springer.com; Annals of Surgical Oncology - http://www.springerlink.com/content/1068-9265/)

Our news journalists report that additional information may be obtained by contacting Steven W. Thorpe, University of California Davis, Dept. of Orthopedic Surgery, Sacramento, CA 95817, United States. Additional authors for this research include Muhammad Umar Jawad, R. Lor Randall, Brad H. Pollock, Elysia Alvarez and Janai R. Carr-Ascher.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1245/s10434-022-11494-4. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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