Organogenesis Comparative Effectiveness Research Demonstrating Faster VLU Time to Healing with Apligraf® Showcased at ISPOR
The research, "Comparative effectiveness of a bilayered living cellular construct and an acellular fetal bovine collagen dressing in the treatment of venous leg ulcers," was e-published ahead of print in the peer-reviewed
"This is the first
Using real-world data from the Net Health WoundExpert® database – the largest independent source of chronic wound benchmarking data in the industry – researchers compared clinical outcomes for the treatment of VLUs among two treatment modalities: Apligraf, a BLCC that is FDA-approved for the treatment of VLUs, and an acellular fetal bovine collagen dressing.
The study found that VLUs treated with Apligraf experienced a 37 percent faster median time to wound closure and that treatment with Apligraf increased the probability of healing by 45 percent when compared to VLUs treated with the acellular fetal bovine collagen dressing.
Chronic venous insufficiency affects approximately 2.5 million Americans, with up to 20 percent developing venous ulceration. Individuals who develop VLUs can often experience delayed healing and VLU recurrence. The impact on the patient's quality of life and the economic cost of this disease can be significant; care for VLUs in
"Apligraf is the first approved bioengineered, living cell based product in
About ISPOR
The leading global professional society for health economics and outcomes research, ISPOR is an international, multidisciplinary society dedicated to advancing the policy, science and practice of pharmacoeconomics and health outcomes research. An unbiased organization comprised of more than 9,500 members from 114 countries, ISPOR and its membership represent the entire field including research, academia, decision and policymaking, payer and patient communities.
About Organogenesis
*De-identified patient data released to
1 https://vascular.org/news-advocacy/venous-ulceration-minimally-invasive-treatment-big-problem,
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