Life Molecular Imaging and National Cyclotron and PET Centre, Chulabhorn Royal Academy, Thailand Announce a Collaboration for Brain PET Imaging with NeuraCeq and PI-2620
The "FDG, Amyloid and Tau Brain PET imaging in Thai Individuals" program is part of the national "Holistic Approach to Alzheimer's Disease in the Thai Population" study. This honorary project aims to integrate scientific knowledge into the standard of care for Alzheimer's disease in
Brain imaging with FDG, NeuraCeq™ and PI-2620 is conducted at the National Cyclotron and PET Centre,
"Life Molecular Imaging continues to expand the availability of innovative molecular imaging agents. We are truly excited about our collaboration with the
Dr. Chanisa Chotipanich, deputy director of
About NeuraCeq™ (florbetaben 18F)
Indication
NeuraCeq™ is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate beta-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) and other causes of cognitive decline.
A negative NeuraCeq™ scan indicates sparse to no amyloid neuritic plaques and is inconsistent with a neuropathological diagnosis of AD at the time of image acquisition; a negative scan result reduces the likelihood that a patient's cognitive impairment is due to AD. A positive NeuraCeq™ scan indicates moderate to frequent amyloid neuritic plaques; neuropathological examination has shown this amount of amyloid neuritic plaque is present in patients with AD but may also be present in patients with other types of neurologic conditions as well as older people with normal cognition. NeuraCeq™ is an adjunct to other diagnostic evaluations.
Limitations of Use
- A positive NeuraCeq™ scan does not establish the diagnosis of AD or any other cognitive disorder.
- Safety and effectiveness of NeuraCeq™ have not been established for (i) predicting development of dementia or other neurologic conditions and (ii) monitoring responses to therapies.
Important Safety Information
Risk for Image Interpretation and Other Errors
NeuraCeq™ can be used to estimate the density of beta-amyloid neuritic plaque deposition in the brain. NeuraCeq™ is an adjunct to other diagnostic evaluations. NeuraCeq™ images should be interpreted independent of a patient's clinical information. Physicians should receive training prior to interpretation of NeuraCeq™ images. Following training, image reading errors (especially false positives) may still occur. Additional interpretation errors may occur due to, but not limited to, motion artifacts or extensive brain atrophy.
Radiation Risk
Administration of NeuraCeq™, similar to other radiopharmaceuticals, contributes to a patient´s overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk of cancer. It is important to ensure safe handling to protect patients and health care workers from unintentional radiation exposure.
Most Common Adverse Reactions
In clinical trials, the most frequently observed adverse drug reactions in 872 subjects with 1090 NeuraCeq™ administrations were injection/application site erythema (1.7%), injection site irritation (1.1%), and injection site pain (3.4%).
About PI-2620
Tau deposits, in conjunction with beta-amyloid plaques, represent the other pathological hallmark of Alzheimer's disease, with tau deposits further playing an important role in other neurodegenerative diseases. PI-2620 is binding to tau deposits and is a next generation 18F-labeled investigational PET tracer with favourable properties and imaging characteristics. It was discovered using the Morphomer™ platform and developed in a research collaboration between Life Molecular Imaging and
About Life Molecular Imaging (LMI)
Life Molecular Imaging (LMI, formerly Piramal Imaging) was formed in 2012 with the acquisition of the molecular imaging research and development portfolio of
Please visit https://life-mi.com.
About
About
Contact person at National Cyclotron and PET Centre:
Ms. Natphimol Boonkawin
Radiochemist
National Cyclotron and PET Centre,
E-mail: koh(dot)natphimol(at)gmail(dot)com
For media queries
Tel: 857-202-1122 | n(dot)fletcher(at)life-mi(dot)com
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