Findings from University of Modena and Reggio Emilia Update Knowledge of Health Maintenance Organizations (Recent advances on separation and…

Findings from University of Modena and Reggio Emilia Update Knowledge of Health Maintenance Organizations (Recent advances on separation and characterization of human milk oligosaccharides)

By a News Reporter-Staff News Editor at Managed Care Weekly Digest -- New research on Health Maintenance Organizations is the subject of a report. According to news reporting out of Modena, Italy, by NewsRx editors, research stated, "Free human milk oligosaccharides (HMOs) are unique due to their highly complex nature and important emerging biological and protective functions during early life such as prebiotic activity, pathogen deflection, and epithelial and immune cell modulation. Moreover, four genetically determined heterogeneous HMO secretory groups are known to be based on their structure and composition."

Our news journalists obtained a quote from the research from the University of Modena and Reggio Emilia, "Over the years, several analytical techniques have been applied to characterize and quantitate HMOs, including nuclear magnetic resonance spectroscopy, high-performance liquid chromatography (HPLC), high pH anion-exchange chromatography, off-line and on-line mass spectrometry (MS), and capillary electrophoresis (CE). Even if these techniques have proven to be efficient and simple, most glycans have no significant UV absorption and derivatization with fluorophore groups prior to separation usually results in higher sensitivity and an improved chromatographic/ electrophoretic profile. Consequently, the analysis by HPLC/CE of derivatized milk oligosaccharides with different chromophoric active tags has been developed. However, UV or fluorescence detection does not provide specific structural information and this is a key point in particular related to the highly complex nature of the milk glycan mixtures. As a consequence, for a specific determination of complex mixtures of oligomers, analytical separation is usually required with evaluation by means of MS, which has been successfully applied to HMOs, resulting in efficient compositional analysis and profiling in various milk samples."

According to the news editors, the research concluded: "This review aims to give an overview of the current state-of-the-art techniques used in HMO analysis."

For more information on this research see: Recent advances on separation and characterization of human milk oligosaccharides. Electrophoresis, 2016;37(11):1514-1524. Electrophoresis can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Electrophoresis - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-2683)

Our news journalists report that additional information may be obtained by contacting V. Mantovani, Univ Modena & Reggio Emilia, Dept. of Life Sci, Via Campi 213-D, I-41100 Modena, Italy. Additional authors for this research include F. Galeotti, F. Maccari and N. Volpi (see also Health Maintenance Organizations).

Keywords for this news article include: Modena, Italy, Europe, Health Maintenance Organizations, Health Insurance, HMO, University of Modena and Reggio Emilia.

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