Data on Aortic Stenosis Reported by Researchers at Tohoku University (Transcatheter Aortic Valve Implantation and Cognitive Function In Elderly Patients With Severe Aortic Stenosis)

2020 APR 29 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Cardiovascular Daily -- Data detailed on Cardiovascular Diseases and Conditions - Aortic Stenosis have been presented. According to news reporting out of Miyagi, Japan, by NewsRx editors, research stated, “The aim of this study was to examine the mechanisms of cognitive impairment and reversibility in elderly patients with severe aortic stenosis (AS) after transcatheter aortic valve implantation (TAVI) with special reference to cerebral blood flow (CBF). We examined 15 elderly patients with severe AS (mean age 83.2 +/- 4.5 years, 12 female) who underwent TAVI.”

Financial support for this research came from Mitsui Sumitomo Insurance Welfare Foundation.

Our news journalists obtained a quote from the research from Tohoku University, “Before and three months after TAVI, we evaluated cognitive function with the Logical Memory II test (LM II), cardiac output (CO) with echocardiography, and CBF with Tc-99m single-photon emission computed tomography (SPECT). LM II score and CO were significantly increased after TAVI compared with baseline (p <0.01 for LM II, p<0.005 for CO). Notably, CBF in the local regions, including that in the right hippocampus, was significantly increased after TAVI (p <0.005 at each voxel). The patients with increased CO after TAVI also showed significantly increased CBF in the right hippocampus compared with those without it (p <0.01). Importantly, CBF in the right hippocampus was positively correlated with LM II scores (p <0.05).”

According to the news editors, the research concluded: “These results provide the first evidence that TAVI may improve cognitive functions associated with increased cerebral perfusion especially in the hippocampus in elderly patients with severe AS.”

For more information on this research see: Transcatheter Aortic Valve Implantation and Cognitive Function In Elderly Patients With Severe Aortic Stenosis. EuroIntervention, 2020;15(18):E1580-+. EuroIntervention can be contacted at: Europa Edition, 19 Allees Jean Jaures B P 61508, Toulouse Cedex 6, 31015, France.

Our news journalists report that additional information may be obtained by contacting H. Shimokawa, Tohoku University, Dept. of Cardiovascular Medicine, Graduate School of Medicine, Sendai, Miyagi, Japan. Additional authors for this research include S. Tsuchiya, Y. Matsumoto, H. Suzuki, Y. Kikuchi, J. Takahashi, S. Miyata, K. Takanami, N. Tomita, H. Arai, K. Kumagai, Y. Saiki and Y. Taki.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.4244/EIJ-D-19-00489. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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