AJMC® Researchers Have 3 Suggestions to Close the Gaps When Creating Value Frameworks for New Medical Therapies

Business Wire

Randomized controlled trials don’t capture real-world evidence regarding how patients will actually interact with, adhere to, or find value in a costly new medical therapy, yet current value frameworks and assessments don’t include this “real world” element. In the current issue of The American Journal of Managed Care^®, authors offer guidance on closing the gap between real-world and clinical trial data when formulating value frameworks.

CRANBURY, N.J.--(BUSINESS WIRE)-- In a commentary in the November issue of The American Journal of Managed Care^® (AJMC^®), health policy and health economics researchers make three recommendations to improve how healthcare system decision makers assess the value of new, potentially costly medical technologies, in light of growing concerns from payers, employers, patients, and other stakeholders.

Value frameworks developed by different organizations may come to separate conclusions about the same drug or treatment, depending on the perspectives and attributes of value that they use. Particularly for chronic diseases, value frameworks need to close the gap between evidence from clinical trials and real-world patient behavior when evaluating new therapies.

To help guide these decisions, the authors formed a working group in 2017, in partnership with Precision Health Economics and Intarcia Therapeutics. The Value FORWARD (Frameworks, Outcomes, and Real-World Adherence in Chronic Disease) Committee aimed to improve upon existing frameworks, and their recommendations are contained in the AJMC® commentary. The authors suggest that value frameworks and assessments:

Integrate real-world effectiveness to complement the efficacy found in randomized controlled trials
Incorporate the way real-world behavior—or patient adherence—mediates outcomes
Discuss how therapies affect real-world equity and disparities in care

Additional resources are needed to understand how human behavior impacts real-world outcomes, causing different results from those seen in clinical trials, the researchers wrote.

For more information, visit www.ajmc.com.

About The American Journal of Managed Care^®

The American Journal of Managed Care^®(AJMC^®) is a peer-reviewed, Medline-indexed journal that keeps readers on the forefront of health policy by publishing research relevant to industry decision makers as they work to promote the efficient delivery of high-quality care. AJMC.com is the essential website for managed care professionals, distributing industry updates daily to leading stakeholders. Other titles in the AJMC^®family include The American Journal of Accountable Care^® and two evidence-based series, Evidence-Based Oncology^™and Evidence-Based Diabetes Management^™. These comprehensive offerings bring together stakeholder views from payers, providers, policymakers and other industry leaders in managed care. To order reprints of articles appearing in AJMC^®publications, please contact Gil Hernandez at 609-716-7777, ext. 139.