University of Tokyo Reports Findings in Lymphangioleiomyomatosis (Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan): Lymphoproliferative Diseases and Conditions – Lymphangioleiomyomatosis

2024 APR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- New research on Lymphoproliferative Diseases and Conditions - Lymphangioleiomyomatosis is the subject of a report. According to news originating from Tokyo, Japan, by NewsRx correspondents, research stated, “Using patient registries or limited regional hospitalization data may result in underestimation of the incidence and prevalence of rare diseases. Therefore, we used the national administrative database to estimate the incidence and prevalence of lymphangioleiomyomatosis over six years (2014-2019) and describe changes in clinical practice and mortality.”

Our news journalists obtained a quote from the research from the University of Tokyo, “We extracted data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan between January 2013 and December 2020. This database covers 99% of the population. We used the diagnostic code for lymphangioleiomyomatosis to estimate the incidence and prevalence from 2014 to 2019. Additionally, we examined the demographic characteristics, treatments, comorbidities, and mortality of the patients. In women, the incidence and prevalence of lymphangioleiomyomatosis in 2019 were approximately 3 per 1,000,000 person-years and 28.7 per 1,000,000 persons, respectively. While, in men, the incidence and prevalence of lymphangioleiomyomatosis were <0.2 per 1,000,000 person-years and 0.8 per 1,000,000 persons, respectively. From 2014 to 2019, the proportion of prescriptions of sirolimus and everolimus increased, while the use of home oxygen therapy, chest drainage, comorbid pneumothorax, and bloody phlegm decreased. The mortality rate remained stable at approximately 1%. The incidence and prevalence of lymphangioleiomyomatosis were higher in women than those reported previously. Although the incidence did not change during the 6-year period, the prevalence gradually increased. Moreover, lymphangioleiomyomatosis was observed to be rare in men.”

According to the news editors, the research concluded: “The practice of treating patients with lymphangioleiomyomatosis changed across the six years while mortality remained low, at approximately 1%.”

This research has been peer-reviewed.

For more information on this research see: Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan. Respiratory Investigation, 2024;62(3):494-502. (Elsevier - www.elsevier.com; Respiratory Investigation - http://www.journals.elsevier.com/respiratory-investigation/)

The news correspondents report that additional information may be obtained from Yuya Kimura, Dept. of Clinical Epidemiology and Health Economics, School of Public Health, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Additional authors for this research include Taisuke Jo, Yohei Hashimoto, Ryosuke Kumazawa, Miho Ishimaru, Hiroki Matsui, Akira Yokoyama, Goh Tanaka and Hideo Yasunaga.

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