University of Tokyo Reports Findings in Alzheimer Disease (Relationship between antidementia medication and fracture prevention in patients with Alzheimer’s dementia using a nationwide health insurance claims database): Neurodegenerative Diseases and Conditions – Alzheimer Disease

Insurance Daily News

2023 MAY 10 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- New research on Neurodegenerative Diseases and Conditions - Alzheimer Disease is the subject of a report. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, “This retrospective study aimed to evaluate the association between antidementia medication use and incidence of new vertebral, hip, and radial fractures in patients with Alzheimer’s dementia (AD). We used the nationwide health insurance claims database of Japan from 2012 to 2019 and identified 12,167,938 patients aged 65 years who were newly registered from April 2012 to March 2016 and had verifiable data receipt from half-year before to 3 years after the registration.”

Our news journalists obtained a quote from the research from the University of Tokyo, “Among these patients, 304,658 were diagnosed with AD and we showed the prescription status of antidementia and osteoporosis medication among them. Propensity score matching was conducted for AD group with and without antidementia medication use, and 122,399 matched pairs were yielded. The incidence of hip fractures (4.0% vs. 1.9%, p< 0.001) and all clinical fractures (10.5% vs. 9.0%, p< 0.001) significantly decreased and that of radial fractures increased (0.6% vs. 1.0%, p< 0.001) in AD patients with antidementia medication use compared with AD patients without antidementia medication use. No significant difference was found in vertebral fractures (6.6% vs. 6.5%, p = 0.51).”

According to the news editors, the research concluded: “Overall, these results suggest a positive relationship between antidementia medication use and fracture prevention in patients with AD.”

For more information on this research see: Relationship between antidementia medication and fracture prevention in patients with Alzheimer’s dementia using a nationwide health insurance claims database. Scientific Reports, 2023;13(1):6893. Scientific Reports can be contacted at: Nature Portfolio, Heidelberger Platz 3, Berlin, 14197, Germany. (Nature Publishing Group - http://www.nature.com/; Scientific Reports - http://www.nature.com/srep/)

Our news journalists report that additional information may be obtained by contacting Mitsutaka Yakabe, Dept. of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. Additional authors for this research include Tatsuya Hosoi, Shoya Matsumoto, Kenji Fujimori, Junko Tamaki, Shinichi Nakatoh, Shigeyuki Ishii, Nobukazu Okimoto, Kuniyasu Kamiya, Masahiro Akishita, Masayuki Iki and Sumito Ogawa.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41598-023-34173-0. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.