Researchers’ Work from Robert Koch-Institute Focuses on Chronic Hepatitis C Virus (Real-world treatment for chronic hepatitis C infection in Germany:…

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Researchers' Work from Robert Koch-Institute Focuses on Chronic Hepatitis C Virus (Real-world treatment for chronic hepatitis C infection in Germany: Analyses from drug prescription data, 2010-2015)

By a News Reporter-Staff News Editor at Insurance Weekly News -- Fresh data on Liver Diseases and Conditions - Chronic Hepatitis C Virus are presented in a new report. According to news originating from Berlin, Germany, by VerticalNews correspondents, research stated, "Direct-acting antivirals (DAAs) for hepatitis C virus (HCV) have strongly improved treatment options since 2014, but it is unclear if treatment numbers have increased. We aimed to estimate the number of treatment regimens per month from 2010-2015 and the number of patients treated and cured with DAAs since 2014, as well as the associated costs."

Our news journalists obtained a quote from the research from Robert Koch-Institute, "Drug prescription data of hepatitis C virus (HCV) antivirals for patients with statutory health insurance in Germany (similar to 85% of population) from January 2010-December 2015 were evaluated. Standard 28-day prescriptions of pegylated interferon (PegIFN) and 1st/2nd generation DAAs were combined according to treatment guidelines and analysed. Drug costs were calculated from pharmacy sales prices. Mean treatment durations/regimen from real-world data were used to calculate drug costs/regimen and numbers of DAA-treated persons in 2014/15. From January 2010-December 2015 PegIFN/ribavirin-treatments/month decreased from similar to 6500 to similar to 650. Monthly HCV-prescriptions rose with the approval of 1st generation DAAs (2011), and decreased at the end of 2013. With the approval of 2nd generation DAAs, prescriptions/month increased (peak: similar to 6600; March 2015), and subsequently decreased (similar to 4000; December 2015). In 2014, similar to 7000 patients were treated with DAAs, and similar to 20,100 in 2015. Treatment costs/month were stable at 12 million EUR (2010-2011), increased to similar to 38 million EUR (March 2012), and peaked to 150 million EUR (March 2015). DAA-drug costs/year added up to similar to 664 million EUR (2014) and similar to 1.3 billion EUR (2015). Despite an increase in DAA prescriptions, in December 2015 less persons/month were under treatment compared to January 2010, even though access to DAAs is not limited. However, yearly treatment numbers increased from 2014-2015. Under observed conditions, similar to 18,000 patients/year can be cured, making substantial reduction of the estimated 160,000 diagnosed patients realizable. Political commitment to achieve further reduce DAA-prices and increase treatment numbers is recommended. Lay summary: New treatment options with all-oral second generation direct-acting antivirals (DAAs) have resulted in the potential to cure chronic hepatitis C infection, but at high costs. Analyses from HCV drug prescription data of patients with statutory health insurance in Germany from 2010-2015, showed that DAAs replaced treatments with pegylated interferon and ribavirin, but accompanied by a disproportionate rise in costs. Although the monthly number of patients under treatment did not increase over time, the total number of patients yearly treated with DAAs increased from similar to 7000 patients in 2014 to similar to 20,100 in 2015, with a trend to shorter treatment regimens."

According to the news editors, the research concluded: "Under observed conditions similar to 18,000 patients can be cured yearly, making a substantial reduction of the estimated 160,000 diagnosed patients in Germany achievable."

For more information on this research see: Real-world treatment for chronic hepatitis C infection in Germany: Analyses from drug prescription data, 2010-2015. Journal of Hepatology, 2017;67(1):15-22. Journal of Hepatology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Hepatology - www.journals.elsevier.com/journal-of-hepatology/)

The news correspondents report that additional information may be obtained from R. Zimmermann, Robert Koch Inst, Dept. of Infect Dis Epidemiol, Berlin, Germany. Additional authors for this research include C. Kollan, P. Ingiliz, S. Mauss, D. Schmidt and V. Bremer.

Keywords for this news article include: Berlin, Germany, Europe, Health Insurance, Diagnostics and Screening, Drugs and Therapies, Digestive System Diseases and Conditions, Infectious Diseases and Conditions, Liver Diseases and Conditions, Chronic Hepatitis C Virus, Flaviviridae Infections, Drug Prescriptions, Gastroenterology, RNA Viruses, Hepatology, Virology, Viral, Robert Koch-Institute.