Researchers at University of Oklahoma Report New Data on Alzheimer Disease (The role of neutrophil granule proteins in neuroinflammation and…

Researchers at University of Oklahoma Report New Data on Alzheimer Disease (The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease)

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been published. According to news originating from Oklahoma City, Oklahoma, by NewsRx correspondents, research stated, "Neutrophils are the innate immune system's first line of defense. Neutrophils play a critical role in protecting the host against infectious pathogens, resolving sterile injuries, and mediating inflammatory responses."

Our news journalists obtained a quote from the research from the University of Oklahoma, "The granules of neutrophils and their constituent proteins are central to these functions. Although neutrophils may exert a protective role upon acute inflammatory conditions or insults, continued activity of neutrophils in chronic inflammatory diseases can contribute to tissue damage. Neutrophil granule proteins are involved in a number of chronic inflammatory conditions and diseases. However, the functions of these proteins in neuroinflammation and chronic neuroinflammatory diseases, including Alzheimer's disease (AD), remain to be elucidated. In this review, we discuss recent findings from our lab and others that suggest possible functions for neutrophils and the neutrophil granule proteins, CAP37, neutrophil elastase, and cathepsin G, in neuroinflammation, with an emphasis on AD. These findings reveal that neutrophil granule proteins may exert both neuroprotective and neurotoxic effects."

According to the news editors, the research concluded: "Further research should determine whether neutrophil granule proteins are valid targets for therapeutic interventions in chronic neuroinflammatory diseases."

For more information on this research see: The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease. Journal of Neuroinflammation, 2018;15():9-23. Journal of Neuroinflammation can be contacted at: Bmc, Campus, 4 Crinan St, London N1 9XW, England. (BioMed Central - www.biomedcentral.com/; Journal of Neuroinflammation - www.jneuroinflammation.com)

The news correspondents report that additional information may be obtained from H.A. Pereira, University of Oklahoma, Dept. of Pathol, Hlth Sci Center, Robert M Bird Lib, Oklahoma City, OK 73117, United States. Additional authors for this research include A. Kasus-Jacobi and A.J. Stock (see also Neurodegenerative Diseases and Conditions - Alzheimer Disease).

Keywords for this news article include: Oklahoma City, Oklahoma, United States, North and Central America, Central Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Brain Diseases and Conditions, Hemic and Immune Systems, Peptides and Proteins, Risk and Prevention, Health and Medicine, Neuroinflammation, Alzheimer Disease, Granulocytes, Neutrophils, Blood Cells, Tauopathies, Phagocytes, Immunology, Dementia, University of Oklahoma.

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