Researchers at Mitsui Memorial Hospital Report New Data on Cardiovascular Research (Clinical Outcomes of Coronary Computed Tomography Angiography-derived Fractional Flow Reserve Dynamic-ffrct Registry One-year Analysis): Cardiovascular Research

2025 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Researchers detail new data in Cardiovascular Research. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, “Coronary computed tomography angiography-derived fractional flow reserve (FFRCT) is useful for noninvasively detecting coronary artery disease. This procedure has been covered by health insurance reimbursement in the United Kingdom, the United States of America, and Japan.”

Financial support for this research came from HeartFlow^® Japan G.K. (Tokyo, Japan).

Our news journalists obtained a quote from the research from Mitsui Memorial Hospital, “This is the first study to investigate the 1-year outcomes of the FFRCT, with management covered by health insurance from the DiscoverY of Novel Assessment Myocardial IsChemia by FFRCT (DYNAMIC-FFRCT) registry. In this multicenter DYNAMIC-FFRCTregistry, 410 participants who underwent FFRCT analysis under health insurance reimbursement were prospectively enrolled at six Japanese sites between October 2019 and November 2021. In accordance with recent guidelines, all participants received appropriate revascularization and/or optimal medication therapy after FFRCT. The following clinical outcomes through the 1-year defined major adverse cardiovascular event (MACE) were investigated: all-cause death, cardiovascular events including non-fatal myocardial infarction, and unplanned hospitalization for acute coronary syndrome leading to revascularization. Of the six MACE cases, four (1.6%) occurred in participants with an FFRCT value <= 0.80, whereas two (1.3%) occurred in a participant with an FFRCT value > 0.80. This analytical study based on the DYNAMIC-FFRCT registry for cardiovascular conditions found no significant difference in 1-year MACE between FFRCT <= 0.80 and > 0.80 following guideline-based therapy. The registry was started shortly after reimbursement and had limited statistical power and selection bias.”

According to the news editors, the research concluded: “Further studies with sufficient statistical power are required.”

This research has been peer-reviewed.

For more information on this research see: Clinical Outcomes of Coronary Computed Tomography Angiography-derived Fractional Flow Reserve Dynamic-ffrct Registry One-year Analysis. International Heart Journal, 2025;66(3):337-344. International Heart Journal can be contacted at: Int Heart Journal Assoc, Univ Tokyo, Graduate School Medicine, Dept Cardiovascular Medicine, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Our news journalists report that additional information may be obtained by contacting Kota Komiyama, Mitsui Memorial Hospital, Division of Cardiology, Izumi Cho Kanda, Chiyoda Ku, Tokyo 1018643, Japan. Additional authors for this research include Kengo Tanabe, Eiji Taguchi, Tomohiro Sakamoto, Rine Nakanishi, Ryo Okubo, Akira Saito, Taku Asano, Akihiro Ikuta, Kazushige Kadota, Yui O. Nozaki and Shinichiro Fujimoto.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1536/ihj.24-534. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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