Research Data from Digestive Disease Center Update Understanding of Chronic Pancreatitis (Association between chronic pancreatitis and urolithiasis:…

Research Data from Digestive Disease Center Update Understanding of Chronic Pancreatitis (Association between chronic pancreatitis and urolithiasis: A population-based cohort study)

By a News Reporter-Staff News Editor at Insurance Weekly News -- Current study results on Digestive System Diseases and Conditions - Chronic Pancreatitis have been published. According to news originating from Changhua, Taiwan, by VerticalNews correspondents, research stated, "Chronic pancreatitis (CP) can cause fat or bile acid malabsorption due to exocrine insufficiency. Fat or bile acid malabsorption has been reported to increase the risk of urolithiasis through increased intestinal oxalate absorption."

Financial support for this research came from Ministry of Health and Welfare.

Our news journalists obtained a quote from the research from Digestive Disease Center, "However, no studies have reported an association between CP and urolithiasis. We identified 15,848 patients (age: greater than or equal to20 years) diagnosed as having CP between 2000 and 2010 from the National Health Insurance Research Database as the study cohort. Beneficiaries without a history of CP were randomly selected and propensity-matched with the study cohort in a 1:4 ratio according to age; sex; comorbidities of hyperlipidemia, diabetes, obesity, hypertension, chronic obstructive pulmonary disease, alcohol-related illness, stroke, and coronary artery disease; and the index date. The prevalence of inflammatory bowel disease (0.44%), hyperparathyroidism (0.10%), or end stage renal disease (1.55%) in CP patients was low, but these comorbidities were also considered in the analysis. All patients were followed until the end of 2011 or withdrawal from the National Health Insurance program to determine the incidence of urolithiasis. The cumulative incidence of urolithiasis was higher in the CP cohort than that in the non-CP cohort (log-rank test, p<0.001) with a 1.89-fold risk of urolithiasis (95% confidence interval [CI]=1.74-2.06). The prevalence of CP was higher in men (81.9%) and in patients younger than 49 years (63.5%; mean age: 48.5 ? 15.3 years). CP was associated with the development of urolithiasis in each age group ( less than or equal to49 years: aHR=2.00, 95% CI=1.81-2.22; 50-64 years: aHR=1.71, 95% CI=1.40-2.09; greater than or equal to65 years: aHR=1.54, 95% CI=1.20-1.98) and each sex (women: aHR=2.10, 95% CI=1.67-2.66; men; aHR=1.86, 95% CI=1.70-2.04). Among the patients without comorbidities, the rate of urolithiasis increased from 2.93/1,000 person-years in non-CP patients to 8.28/1,000 person-years in CP patients. Among the patients with comorbidities, the rate of urolithiasis increased from 6.12/1,000 person-years in non-CP patients to 10.9/1,000 person-years in CP patients. The contribution of CP to the relative risk of urolithiasis was greater in patients without comorbidities (without comorbidities: aHR=2.81, 95% CI=2.30-3.44) than in those with comorbidities (aHR=1.76, 95% CI=1.61-1.94). CP is associated with urolithiasis in this population-based cohort study. The contribution of CP to the relative risk of urolithiasis was even greater in patients with a lower risk of urolithiasis, such as those without other comorbidities."

According to the news editors, the research concluded: "Our findings warrant a survey and education on urolithiasis for patients with CP."

For more information on this research see: Association between chronic pancreatitis and urolithiasis: A population-based cohort study. Plos One, 2018;13(3):e0194019. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

The news correspondents report that additional information may be obtained from C.H. Chen, Digestive Disease Center, Show-Chwan Memorial Hospital, Changhua, Taiwan. Additional authors for this research include C.L. Lin and L.B Jeng.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1371/journal.pone.0194019. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Asia, Taiwan, Changhua, Epidemiology, Gastroenterology, Health Insurance, Clinical Research, Health and Medicine, Insurance Companies, Risk and Prevention, Chronic Pancreatitis, Clinical Trials and Studies, Pancreatic Diseases and Conditions, Digestive System Diseases and Conditions.

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