New Findings on Neurourology and Urodynamics Discussed by Researchers at Nara Medical University School of Medicine (Association between NT-proBNP and nocturia among community-dwelling elderly males and females: A cross-sectional analysis of …)

2020 NOV 04 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Women’s Health Daily -- New research on Urology - Neurourology and Urodynamics is the subject of a report. According to news reporting originating in Nara, Japan, by NewsRx journalists, research stated, “To investigate the association between B-type natriuretic peptide (BNP) and nocturia among community-dwelling males and females. A total of 1096 participants (mean age 71.9 ? 7.1 years, 518 [47.2%] males) were included in the study.”

Funders for this research include Osaka Gas Group Welfare Foundation, Japan Diabetes Foundation, Meiji Yasuda Life Foundation of Health and Welfare, Mitsui Sumitomo Insurance Welfare Foundation, Japan Science and Technology Agency, Daiwa Securities Health Foundation, Nara Medical University.

The news reporters obtained a quote from the research from the Nara Medical University School of Medicine, “The number of nocturnal voids was recorded in a self-reported urination diary, and nocturia was defined as two or more voids per night. Daytime serum concentration of the N-terminal fragment of BNP precursor (NT-proBNP) was measured. Multivariable logistic regression analysis was performed to determine the association between NT-proBNP and nocturia. Nocturia was observed in 23.5% of females and 37.1% of males. Higher NT-proBNP (log pg/ml) was associated with nocturia in both gender groups (females: odds ratio [OR]: 1.67, 95% confidence interval [95% CI], 1.21-2.34, p=.002; males: OR: 1.26, 95% CI, 1.01-1.59, p=.046), independent of confounding variables including night-time blood pressure, mean voided volume, and chronic kidney disease. Although the increase in prevalence of nocturia with higher NT-proBNP was equivalent in both genders, some effect of gender on the relationship between NT-proBNP and nocturia was observed (p=.037). Nocturnal urine volume was also significantly and independently associated with NT-proBNP level (females: b=32.9 ml, 95% CI, 5.63-60.2, p=.018; males: b=34.6 ml, 95% CI, 9.40-59.9, p=.007). This study revealed higher serum NT-proBNP is significantly and independently associated with the prevalence of nocturia in both males and females.”

According to the news reporters, the research concluded: “This is an exploratory cross-sectional study and the analyses are post hoc, so further research works are needed to clarify the causality and clinical value.”

This research has been peer-reviewed.

For more information on this research see: Association between NT-proBNP and nocturia among community-dwelling elderly males and females: A cross-sectional analysis of the HEIJO-KYO study. Neurourology and Urodynamics, 2020. Neurourology and Urodynamics can be contacted at: Wiley-Liss, Div John Wiley & Sons Inc, 111 River St, Hoboken, NJ 07030, USA. (Wiley-Blackwell - http://www.wiley.com/; Neurourology and Urodynamics - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6777)

Our news correspondents report that additional information may be obtained by contacting Kenji Obayashi, Dept. of Epidemiology, Nara Medical University School of Medicine, Nara, Japan. Additional authors for this research include Kazuki Okumura, Yoshiaki Tai, Yuki Yamagami, Hiromitsu Negoro, Hiroshi Kataoka, Norio Kurumatani and Keigo Saeki.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1002/nau.24550. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

The publisher of the journal Neurourology and Urodynamics can be contacted at: Wiley-Liss, Div John Wiley & Sons Inc, 111 River St, Hoboken, NJ 07030, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)