New Findings from University of Washington Medical Center in the Area of Parkinson’s Disease Reported (Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson’s disease)

2020 JUN 29 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- New research on Neurodegenerative Diseases and Conditions - Parkinson’s Disease is the subject of a report. According to news reporting originating from Seattle, Washington, by NewsRx correspondents, research stated, “Imaging neurovascular disturbances in Parkinson’s disease (PD) is an excellent measure of disease severity. Indeed, a disease-specific regional pattern of abnormal metabolism has been identified using positron emission tomography.”

Funders for this research include National Institute on Aging, Pacific Udall Center, Dolsen Family Fund.

Our news editors obtained a quote from the research from the University of Washington Medical Center, “Only a handful of studies, however, have applied perfusion MRI to detect this disease pattern. Our goal was to replicate the evaluation of a PD-related perfusion pattern using scaled subprofile modeling/principal component analysis (SSM-PCA). We applied arterial spin labeling (ASL) MRI for this purpose. Uniquely, we assessed this pattern separately in PD individuals ON and OFF dopamine medications. We further compared the existence of these patterns and their strength in each individual with their Movement Disorder Society-Unified Parkinson’s Disease Rating Scale motor (MDS-UPDRS) scores, cholinergic tone as indexed by short-term afferent inhibition (SAI), and other neuropsychiatric tests. We observed a PD-related perfusion pattern that was similar to previous studies. The patterns were observed in both ON and OFF states but only the pattern in the OFF condition could significantly (AUC=0.72) differentiate between PD and healthy subjects. In the ON condition, PD subjects were similar to controls from a CBF standpoint (AUC=0.45). The OFF pattern prominently included the posterior cingulate, precentral region, precuneus, and the subcallosal cortex. Individual principal components from the ON and OFF states were strongly associated with MDS-UPDRS scores, SAI amplitude and latency.”

According to the news editors, the research concluded: “Using ASL, our study identified patterns of abnormal perfusion in PD and were associated with disease symptoms.”

For more information on this research see: Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson’s disease. Parkinsonism and Related Disorders, 2020;76():21-28. Parkinsonism and Related Disorders can be contacted at: Elsevier Sci LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Parkinsonism and Related Disorders - http://www.journals.elsevier.com/parkinsonism-and-related-disorders/)

The news editors report that additional information may be obtained by contacting S. Rane, Integrated Brain Imaging Center, Radiology, University of Washington Medical Center, Seattle, WA, United States. Additional authors for this research include N. Koh, J. Oakley, C. Caso, C.P. Zabetian, B. Cholerton, T.J. Montine and T. Grabowski.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.parkreldis.2020.05.014. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Parkinsonism and Related Disorders is: Elsevier Sci LTD, the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England.

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