New Atrial Fibrillation Findings Has Been Reported by Researchers at Institute of Population Health Sciences (Association between Nonsteroidal…

Managed Care Weekly Digest

New Atrial Fibrillation Findings Has Been Reported by Researchers at Institute of Population Health Sciences (Association between Nonsteroidal Anti-inflammatory Drugs and Atrial Fibrillation among a Middle-aged Population: A Nationwide ...)

By a News Reporter-Staff News Editor at Managed Care Weekly Digest -- New research on Heart Disorders and Diseases - Atrial Fibrillation is the subject of a report. According to news reporting originating from Miaoli, Taiwan, by NewsRx correspondents, research stated, "It remains inconclusive whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of atrial fibrillation (AF), especially in middle-aged Asian populations. In this study, we evaluated the association between NSAID use and the risk of AF in a nationwide population-based study of middle-aged individuals in Taiwan."

Our news editors obtained a quote from the research from the Institute of Population Health Sciences, "A nested case-control study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan. We identified the cases with a diagnosis of AF (ICD-9-CM codes: 427.31) and the matched controls from three independent Longitudinal Health Insurance Databases (LHIDs) derived from the NHIRD from data collected from 2001 to 2013. Conditional logistic regression models with covariates adjustment were performed to evaluate the association between NSAID use and the risk of AF. A total of 57,058 participants (28,529 AF cases and 28,529 matched controls) were included. Participants with NSAID use had an elevated risk of AF compared to non-users (adjusted odds ratio (AOR)=1.18, 95% confidence interval (CI): 1.14-1.23). When further assessing the effects of different classes of NSAIDs on the risk of AF, the results showed that participants who used non-selective NSAIDs had a significantly elevated risk of AF (AOR=1.18, 95%CI: 1.13-1.23), as did participants with a combined use of selective and non-selective NSAIDs (AOR=1.30, 95%CI: 1.21-1.39). NSAID use was associated with an increased risk of AF occurrence among the participants included in our study cohort."

According to the news editors, the research concluded: "Closely monitoring the adverse effects of NSAID treatment on the risk of AF will be important, particularly among individuals at high risk."

For more information on this research see: Association between Nonsteroidal Anti-inflammatory Drugs and Atrial Fibrillation among a Middle-aged Population: A Nationwide Population-based Cohort. British Journal of Clinical Pharmacology, 2018;():. (Wiley-Blackwell - www.wiley.com/; British Journal of Clinical Pharmacology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2125)

The news editors report that additional information may be obtained by contacting S.Y. Chuang, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan. Additional authors for this research include P.F. Hsu, F.J. Lin, Y.W. Huang, G.Z. Wang, W.C. Chang and H.J Tsai (see also Heart Disorders and Diseases - Atrial Fibrillation).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/bcp.13558. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Asia, Miaoli, Taiwan, Epidemiology, Heart Disease, Health Insurance, Atrial Fibrillation, Cardiac Arrhythmias, Drugs and Therapies, Health and Medicine, Risk and Prevention, Heart Disorders and Diseases, Non Steroidal Antiinflammatory Agents, Non Steroidal Anti Inflammatory Agents.