Studies from AstraZeneca Yield New Information about Asthma (The Use of Short-acting Bronchodilators and Cost Burden of Asthma Across Global Initiative for Asthma-based Severity Levels: Insights From a Large Us Commercial and Managed Medicaid …): Lung Diseases and Conditions – Asthma

2022 SEP 07 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Business Daily -- Researchers detail new data in Lung Diseases and Conditions - Asthma. According to news reporting from Wilmington, Delaware, by NewsRx journalists, research stated, “Despite the availability of effective treatments, patients with asthma, regardless of severity, remain at risk of severe exacerbations resulting in significant burden to patients, the health care system, and insurance providers. To examine severe exacerbations, treatment patterns, health care resource utilization (HCRU), and costs across all asthma severities.”

Financial support for this research came from AstraZeneca.

The news correspondents obtained a quote from the research from AstraZeneca, “In this retrospective study, patients aged 4 years and older filling 1 short-acting beta(2)-agonist (SABA) and at least 1 maintenance fill or at least 2 SABAs with or without maintenance fills were identified from administrative claims data from the IBM MarketScan Commercial and IBM MarketScan Multistate Medicaid Research databases (January 2010 to December 2017). Patients were indexed on a random SABA fill (2011-2016) and had 12 months of continuous eligibility pre-index and post-index. Patients were classified into Global Initiative for Asthma (GINA) 2018 severity steps and by asthma control, as measured by SABA fill use in the 12 months pre-index: tow (1 SABA fill per year), medium (2-3 SABA fills per year), and high (>= 4 SABA fills per year); well controlled, not welt controlled, and very poorly controlled, respectively. Severe asthma exacerbation events, health care costs, and asthma-related HCRU and costs were assessed relative to asthma severity and asthma control post-index. Of 1,005,522 patients, 50.3% filled GINA Step 1; 19.7% GINA Step 2;10.9% GINA Step 3; and 19.1% GINA Steps 4-5 treatments. Overall, 953,337 severe exacerbation events occurred (approximately 0.9$ events per patient), equating to 0.96, 0.67, 0.83, and 1.28 events per patient for patients filling GINA Step 1 through Steps 4-5, respectively. GINA Step 1 had the highest proportion of patients experiencing at least 1 event (57.0%), followed by GINA Steps 4-5 (55.2%), GINA Step 3 (45.0%), and GINA Step 2 (41.9%) treatments (P <0.05). For GINA Step 1, 64.4% of well-controlled patients experienced at least 1 exacerbation event vs 50.4% of not welt-controlled and 53.0% of very poorly controlled patients (P <0.05). For patients fitting GINA Step 2-5 treatments, a greater proportion of very poorly controlled patients experienced at least 1 exacerbation event vs well-controlled patients (P <0.05). The average total annual health care cost per patient was 57,148 and total annual asthma-related costs were $1,741. Each additional SABA fill was associated with a 26.0%, 10.8%, and 34.6% increase in incidence of total exacerbations, alt-cause costs, and asthma-related costs, respectively (P <0.05). In this real-world database study, increased SABA fills and occurrence of exacerbations were correlated and associated with higher all-cause and asthma-related costs across all severities.”

According to the news reporters, the research concluded: “New treatment paradigms, particularly for rescue therapies, are warranted to improve clinical and cost outcomes in these patients.”

This research has been peer-reviewed.

For more information on this research see: The Use of Short-acting Bronchodilators and Cost Burden of Asthma Across Global Initiative for Asthma-based Severity Levels: Insights From a Large Us Commercial and Managed Medicaid Population. Journal of Managed Care & Specialty Pharmacy, 2022;28(8):881-891. Journal of Managed Care & Specialty Pharmacy can be contacted at: Acad Managed Care Pharmacy, 100 N Pitt St, 400, Alexandria, VA 22314-3134, USA.

Our news journalists report that additional information may be obtained by contacting Michael Pollack, AstraZeneca, BioPharmaceut Med Usa, Wilmington, DE 19803, United States. Additional authors for this research include Hitesh Gandhi, Ileen Gilbert, Joseph Tkacz, Njira Lugogo and Miguel Lanz.

(Our reports deliver fact-based news of research and discoveries from around the world.)