Reports on Risk Management Findings from Naval Surface Warfare Center Provide New Insights (Dose-Response Modeling for Inhalational Anthrax in…

Reports on Risk Management Findings from Naval Surface Warfare Center Provide New Insights (Dose-Response Modeling for Inhalational Anthrax in Rabbits Following Single or Multiple Exposures)

By a News Reporter-Staff News Editor at Insurance Weekly News -- Research findings on Risk Management are discussed in a new report. According to news reporting from Dahlgren, Virginia, by VerticalNews journalists, research stated, "There is a need to advance our ability to characterize the risk of inhalational anthrax following a low-dose exposure. The exposure scenario most often considered is a single exposure that occurs during an attack."

The news correspondents obtained a quote from the research from Naval Surface Warfare Center, "However, long-term daily low-dose exposures also represent a realistic exposure scenario, such as what may be encountered by people occupying areas for longer periods. Given this, the objective of the current work was to model two rabbit inhalational anthrax dose-response data sets. One data set was from single exposures to aerosolized Bacillus anthracis Ames spores. The second data set exposed rabbits repeatedly to aerosols of B. anthracis Ames spores. For the multiple exposure data the cumulative dose (i.e., the sum of the individual daily doses) was used for the model. Lethality was the response for both. Modeling was performed using Benchmark Dose Software evaluating six models: logprobit, loglogistic, Weibull, exponential, gamma, and dichotomous-Hill. All models produced acceptable fits to either data set. The exponential model was identified as the best fitting model for both data sets. Statistical tests suggested there was no significant difference between the single exposure exponential model results and the multiple exposure exponential model results, which suggests the risk of disease is similar between the two data sets."

According to the news reporters, the research concluded: "The dose expected to cause 10% lethality was 15,600 inhaled spores and 18,200 inhaled spores for the single exposure and multiple exposure exponential dose-response model, respectively, and the 95% lower confidence intervals were 9,800 inhaled spores and 9,200 inhaled spores, respectively."

For more information on this research see: Dose-Response Modeling for Inhalational Anthrax in Rabbits Following Single or Multiple Exposures. Risk Analysis, 2016;36(11):2031-2038. (Wiley-Blackwell - www.wiley.com/; Risk Analysis - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1539-6924)

Our news journalists report that additional information may be obtained by contacting B.W. Gutting, CBR Concepts and Experimentation Branch (B21), Naval Surface Warfare Center, Dahlgren Division, Dahlgren, VA, United States. Additional authors for this research include A. Rukhin, D. Marchette, R.S. Mackie and B. Thran.

Keywords for this news article include: Dahlgren, Virginia, United States, Risk Management, Risk and Prevention, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC