Recent Findings from Risk Sciences International Advance Knowledge in Risk Management (Recent Advances in Probabilistic Dose-Response Assessment to Inform Risk-Based Decision Making)

2020 OCT 01 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Researchers detail new data in Risk Management. According to news reporting out of Ottawa, Canada, by NewsRx editors, research stated, “Paradoxically, risk assessments for the majority of chemicals lack any quantitative characterization as to the likelihood, incidence, or severity of the risks involved. The relatively few cases where ‘risk’ is truly quantified are based on either epidemiologic data or extrapolation of experimental animal cancer bioassay data.”

Financial support for this research came from National Institute of Environmental Health Sciences.

Our news journalists obtained a quote from the research from Risk Sciences International, “The paucity of chemicals and health endpoints for which such data are available severely limits the ability of decisionmakers to account for the impacts of chemical exposures on human health. The development by the World Health Organization International Programme on Chemical Safety (WHO/IPCS) in 2014 of a comprehensive framework for probabilistic dose-response assessment has opened the door to a myriad of potential advances to better support decision making. Building on the pioneering work of Evans, Hattis, and Slob from the 1990s, the WHO/IPCS framework provides both a firm conceptual foundation as well as practical implementation tools to simultaneously assess uncertainty, variability, and severity of effect as a function of exposure. Moreover, such approaches do not depend on the availability of epidemiologic data, nor are they limited to cancer endpoints. Recent work has demonstrated the broad feasibility of such approaches in order to estimate the functional relationship between exposure level and the incidence or severity of health effects.”

According to the news editors, the research concluded: “While challenges remain, such as better characterization of the relationship between endpoints observed in experimental animal or in vitro studies and human health effects, the WHO/IPCS framework provides a strong basis for expanding the breadth of risk management decision contexts supported by chemical risk assessment.”

For more information on this research see: Recent Advances in Probabilistic Dose-Response Assessment to Inform Risk-Based Decision Making. Risk Analysis, 2020;():. Risk Analysis can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA. (Wiley-Blackwell - http://www.wiley.com/; Risk Analysis - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1539-6924)

Our news journalists report that additional information may be obtained by contacting Greg M. Paoli, Risk Sciences International, Ottawa, ON, Canada.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/risa.13595. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Risk Analysis is: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA.

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