New Inflammatory Bowel Disease Findings from National Taiwan University Hospital and School of Medicine Described (Rosiglitazone Does Not Affect the Risk of Inflammatory Bowel Disease: A Retrospective Cohort Study in Taiwanese Type 2 Diabetes …): Digestive System Diseases and Conditions – Inflammatory Bowel Disease

2023 MAY 12 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Current study results on inflammatory bowel disease have been published. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, “Human studies on the effect of rosiglitazone on inflammatory bowel disease (IBD) are still lacking. We investigated whether rosiglitazone might affect IBD risk by using the reimbursement database of Taiwan’s National Health Insurance to enroll a propensity-score-matched cohort of ever users and never users of rosiglitazone.”

Funders for this research include Ministry of Science And Technology.

Our news journalists obtained a quote from the research from National Taiwan University Hospital and School of Medicine: “The patients should have been newly diagnosed with diabetes mellitus between 1999 and 2006 and should have been alive on 1 January 2007. We then started to follow the patients from 1 January 2007 until 31 December 2011 for a new diagnosis of IBD. Propensity-score-weighted hazard ratios were estimated with regards to rosiglitazone exposure in terms of ever users versus never users and in terms of cumulative duration and cumulative dose of rosiglitazone therapy for dose-response analyses. The joint effects and interactions between rosiglitazone and risk factors of psoriasis/arthropathies, dorsopathies, and chronic obstructive pulmonary disease/tobacco abuse and the use of metformin were estimated by Cox regression after adjustment for all covariates. A total of 6226 ever users and 6226 never users were identified and the respective numbers of incident IBD were 95 and 111. When we compared the risk of IBD in ever users to that of the never users, the estimated hazard ratio (0.870, 95% confidence interval: 0.661-1.144) was not statistically significant. When cumulative duration and cumulative dose of rosiglitazone therapy were categorized by tertiles and hazard ratios were estimated by comparing the tertiles of rosiglitazone exposure to the never users, none of the hazard ratios reached statistical significance. In secondary analyses, rosiglitazone has a null association with Crohn’s disease, but a potential benefit on ulcerative colitis (UC) could not be excluded. However, because of the low incidence of UC, we were not able to perform detailed dose-response analyses for UC.”

According to the news reporters, the research concluded: “In the joint effect analyses, only the subgroup of psoriasis/arthropathies (-)/rosiglitazone (-) showed a significantly lower risk in comparison to the subgroup of psoriasis/arthropathies (+)/rosiglitazone (-). No interactions between rosiglitazone and the major risk factors or metformin use were observed. We concluded that rosiglitazone has a null effect on the risk of IBD, but the potential benefit on UC awaits further investigation.”

For more information on this research see: Rosiglitazone Does Not Affect the Risk of Inflammatory Bowel Disease: A Retrospective Cohort Study in Taiwanese Type 2 Diabetes Patients. Pharmaceuticals, 2023,16(5). (Pharmaceuticals - http://www.mdpi.com/journal/pharmaceuticals/). The publisher for Pharmaceuticals is MDPI AG.

A free version of this journal article is available at https://doi.org/10.3390/ph16050679.

Our news editors report that additional information may be obtained by contacting Chin-Hsiao Tseng, Department of Internal Medicine, National Taiwan University Hospital and School of Medicine, Taipei 10051, Taiwan.

ORCID is an identifier for authors and includes bibliographic information. The following is ORCID information for the author of this research: Chin-Hsiao Tseng (http://orcid.org/0000-0001-9545-7123).

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