National Health Insurance Service Ilsan Hospital Reports Findings in Iron-Deficiency Anemia (Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control …): Nutritional and Metabolic Diseases and Conditions – Iron-Deficiency Anemia

2023 OCT 02 (NewsRx) -- By a News Reporter-Staff News Editor at Information Technology Business Daily -- New research on Nutritional and Metabolic Diseases and Conditions - Iron-Deficiency Anemia is the subject of a report. According to news originating from Goyang, South Korea, by NewsRx correspondents, research stated, “Menorrhagia is a common cause of iron deficiency anemia (IDA) in premenopausal women. However, the effects of menorrhagia on IDA in premenopausal women have been underestimated compared to those on other IDA-related disorders (IRDs) such as gastrointestinal malignancies (GIMs).”

Our news journalists obtained a quote from the research from National Health Insurance Service Ilsan Hospital, “To better understand the relationship between menorrhagia and IDA in premenopausal women, we analyzed the National Health Insurance Service-National Health Information Database (NHIS-NHID). From 2005 to 2008, data about women between the age of 20 and 59 years were extracted from the NHIS-NHID to create a propensity score-matched case (IDA) and control group. The annual incidence of IDA was calculated per age group. A 10-year follow up of the study population was determined to detect IRDs in case and control groups. We compared the risk of detection (ROD) of IRDs, including GIM and gynecological disorders associated with menorrhagia - leiomyoma of uterus (LM) and adenomyosis (AM), in the case and the control group. From 2005 to 2008, women diagnosed with IDA (n = 535,249) and healthy women as a control group (n = 1,070,498) were identified from the NHIS-NHID. The annual incidence of IDA was 767.4 (2005), 948.7 (2006), 981.6 (2007), and 897.7 (2008) per 100,000 women. The age distribution of IDA was similar each year; IDA was common in women aged 30-39 years (36-37%) and 40-49 years (30-32%), and its incidence was significantly decreased in women aged 50-59 years (< 10%). The ROD of IRDs were significantly higher in the IDA group than in the control group (LM: 20.8% vs. 6.9%, AM: 5.6% vs. 1.6%, and GIM: 2.6% vs. 0.7%). The corresponding hazard ratios were 3.89 (95% confidence interval [CI], 3.85-3.93) for LM, 4.99 (95% CI, 4.90-5.09) for AM, and 3.43 (95% CI, 3.32-3.55) for GIM. The ROD of the IRDs varied; the ROD of LM in the IDA group increased with age and decreased in the age group 50-59 years. AM was more frequently detected in women with IDA aged 30-39 years and less in women older than 40 years. The frequency of GIM increased with age. In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women.”

According to the news editors, the research concluded: “Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.”

For more information on this research see: Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea. Journal of Korean Medical Science, 2023;38(37). Journal of Korean Medical Science can be contacted at: Korean Acad Medical Sciences, 302 75 Dong Du Ichon, Dong Yongsan Ku, Seoul 140 031, South Korea.

The news correspondents report that additional information may be obtained from Haeyong Pak, Dept. of Research and Analysis, National Health Insurance Service Ilsan Hospital, Goyang, South Korea. Additional authors for this research include Hyun Jung Lee, Jae Joon Han and Myung Hee Chang.

The publisher’s contact information for the Journal of Korean Medical Science is: Korean Acad Medical Sciences, 302 75 Dong Du Ichon, Dong Yongsan Ku, Seoul 140 031, South Korea.

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