Findings from Department of Obstetrics and Gynecology in the Area of Cervical Cancer Described (Long-term Impact of Surgical Route and Tumor Size On Risk of Recurrence Among Early-stage Cervical Cancer Patients In a Managed Care Population): Oncology – Cervical Cancer

2025 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- Researchers detail new data in Oncology - Cervical Cancer. According to news reporting originating from San Francisco, California, by NewsRx correspondents, research stated, “This study aimed to compare survival outcomes between minimally invasive surgery (MIS) and open surgery for early-stage cervical cancer in a managed care community patient population. This retrospective study included adult patients who underwent a hysterectomy or trachelectomy for a pre-operative clinical-pathologic diagnosis of stage IA1 to IIA1 cervical cancer as defined by the International Federation of Gynecology and Obstetrics 2018 cervical cancer staging.”

Our news editors obtained a quote from the research from the Department of Obstetrics and Gynecology, “Patients were diagnosed with cervical cancer between January 2005 and December 2018 at a Kaiser Permanente Northern California hospital. We compared outcomes between patients with stage IA2 to IIA1 cervical cancer who underwent a radical MIS and those who underwent open surgery. We separately analyzed patients with stage IA1 disease. A total of 227 patients (55%) with stage IA2 to IIA1 disease underwent MIS and were compared with 187 patients (45%) in the open cohort. In most cases, MIS involved robotic-assisted surgery (77%). The median length of follow-up was 82.6 months (interquartile range; 53.8-106.4) for MIS and 156.6 months (interquartile range; 139.1-168.7) for the open group. There were 27 recurrences in the MIS group (12%) and 8 recurrences in the open group (4%) (p < .01). The 10-year recurrence-free survival was significantly lower in the MIS group (87%, 95% CI 81.0% to 90.7%) than in the open group (97%, 95% CI 92.4% to 98.4%, p< .01). Among patients with tumor size <2 cm, the 10-year recurrence-free survival was significantly lower with MIS (89%, 95% CI 82.7% to 93.5%) than with open surgery (98%, 95% CI 92.3% to 99.5%, p< .01). The 10-year disease-specific survival was also inferior for MIS (96%, 95% CI 92.0% to 98.2%) than for open surgery (100%, 95% CI 100% to 100%, p< .01). None of the 133 patients with stage IA1 disease experienced a cancer recurrence, regardless of surgical approach. Prior cone biopsy was associated with a lower risk of recurrence (adjusted HR 0.48, 95% CI 0.22 to 1.03). Patients with stage IA2 to IIA1 cervical cancer, including those with tumors <2 cm, had inferior survival outcomes following MIS compared with open surgery.”

According to the news editors, the research concluded: “Patients with stage IA1 cervical cancer have a very low risk of recurrence regardless of surgical approach.”

This research has been peer-reviewed.

For more information on this research see: Long-term Impact of Surgical Route and Tumor Size On Risk of Recurrence Among Early-stage Cervical Cancer Patients In a Managed Care Population. International Journal of Gynecologic Cancer, 2025;35(7). International Journal of Gynecologic Cancer can be contacted at: Bmj Publishing Group, British Med Assoc House, Tavistock Square, London WC1H 9JR, England.

The news editors report that additional information may be obtained by contacting Allison H. Kay, Kaiser Permanente San Francisco, Dept. of Obstetrics and Gynecology, Division of Gynecologic Oncology, San Francisco, CA 94115, United States. Additional authors for this research include Rosa A. Guerra, Ramey Littell and Lue-Yen Tucker.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ijgc.2025.101928. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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