Findings from Asan Medical Center Broaden Understanding of Alzheimer Disease (Body mass index trajectories and the risk for Alzheimer’s disease among older adults)

2021 FEB 19 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Data detailed on Alzheimer disease have been presented. According to news originating from the Asan Medical Center by NewsRx editors, the research stated, “The effect of body mass index (BMI) changes and variability on the risk for Alzheimer’s disease (AD) remains unclear. We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002-2003), phase 2 (2004-2005), and phase 3 (2006-2007), of the Korean National Health Insurance Service-Health Screening Cohort.”

Our news correspondents obtained a quote from the research from Asan Medical Center: “We evaluated the effect of 2- and 4-year BMI changes and BMI variability on the risk of AD using Cox regression models. In men, association between 2-year BMI changes, BMI variability, and the risk of AD was not significant. Risk of AD was higher in men whose BMI had decreased 10.1-15.0% over 4 years. In women, aHRs and 95% CIs for AD were 1.14 (1.02-1.29), 1.44 (1.17-1.79), and 1.51 (1.09-2.09) when 2-year BMI loss was 5.1-10.0%, 10.1-15.0%, and > 15.0%. The HRs for AD in women significantly increased when 4-year BMI loss was > 5.0%. The aHR and 95% CI for AD was 1.31 (1.17-1.46) in the 4th quartile of average successive variability (ASV) compared with the 1st quartile of ASV in women.”

According to the news reporters, the research concluded: “BMI loss over 2- and 4-year period was associated with increased risk for AD, and risk increased in women with higher BMI variability. Appropriate body weight management is recommended to prevent AD.”

For more information on this research see: Body mass index trajectories and the risk for Alzheimer’s disease among older adults. Scientific Reports, 2021,11(1):1-10. (Scientific Reports - http://www.nature.com/srep/index.html). The publisher for Scientific Reports is Nature Publishing Group.

A free version of this journal article is available at https://doi.org/10.1038/s41598-021-82593-7.

Our news editors report that more information may be obtained by contacting Seo Young Kang, International Healthcare Center, Asan Medical Center. Additional authors for this research include Ye-Jee Kim, Wooyoung Jang, Ki Young Son, Hye Soon Park, Young Sik Kim.

(Our reports deliver fact-based news of research and discoveries from around the world.)