The Dow ended the day down 170.37 points, or 0.65 percent, while the S&P 500 dropped 0.36 percent and the Nasdaq Composite was up 0.15 percent.
Stocks that would benefit most from the lifting of restrictions put in place to prevent the spread of the coronavirus such as airlines, cruise lines and retail struggled on Wednesday.
Additionally, Nordstrom stock fell 5.54 percent and Gap dropped 5.49 percent.
Tech stocks, however, outperformed the rest of the market allowing the tech-heavy Nasdaq to end the day with gains.
Netflix stock rose 2.67 percent, Amazon gained 0.98 percent and
Stocks were also affected by
Wednesday's losses came after the markets started the week with gains with the Dow closing up 526 points on Tuesday.