Studies from University Hospital Toulouse Describe New Findings in Alzheimer Disease (Alzheimer’s Disease and Related Syndromes and hospitalization: a nationwide 5-year longitudinal study)

2020 APR 29 (NewsRx) -- By a News Reporter-Staff News Editor at Hospital & Nursing Home Daily -- Current study results on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been published. According to news reporting out of Toulouse, France, by NewsRx editors, research stated, “To study the association between Alzheimer’s disease and Related Syndromes (ADRS) and the incidence of short-stay hospitalizations from the year before (Y-1) to 4 years after (Y1 to Y4) ADRS identification in the healthcare system. Among all beneficiaries of the French health insurance general scheme aged 40 or more, those with an incident ADRS in 2011, identified through long-term disease registry, hospitalization diagnoses, or ADRS-specific drug delivery, were matched with beneficiaries without an ADRS of same age, gender, and residence area.”

Our news journalists obtained a quote from the research from University Hospital Toulouse, “The annual incidence rates of all-causes hospitalizations (excluding those with a diagnosis code of ADRS) were compared between individuals with or without an ADRS using incidence ratios (IRs), globally and by age, gender, deprivation index and modified Charlson score. We also studied cause-specific hospitalizations, using patient’s diagnoses and procedures codes. 90871 subjects with an ADRS and 90871 without were included (mean age: 79.6, 66% females). From Y-1 to Y4, incidence rates were significantly higher in subjects with an ADRS than in those without, for all-causes hospitalization (IR(Y )=1.73 [95% confidence interval: 1.71-1.75]; IR(Y )=1.37 [1.35-1.39]), hospitalizations for social reasons (IR(Y )=4.28; IR(Y )=2.70), fall (IR(Y )=5.36; IR(Y )=2.59), injury (IR(Y )=2.71; IR(Y )=2.09), and infection (IR(Y )=2.04; IR(Y )=2.07). The inverse was observed for hospitalizations for cataract surgery (IR(Y )=0.73; IR(Y )=0.51) or total hip prosthesis after 2 years (IR(Y )=0.72). Incident ADRS cases were associated with a higher incidence of hospitalizations, but these subjects used less frequently some non-emergency common surgeries.”

According to the news editors, the research concluded: “Future studies need to assess the clinical impact of these differences.”

For more information on this research see: Alzheimer’s Disease and Related Syndromes and hospitalization: a nationwide 5-year longitudinal study. European Journal of Neurology, 2020;():. European Journal of Neurology can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA. (Wiley-Blackwell - http://www.wiley.com/; European Journal of Neurology - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-1331)

Our news journalists report that additional information may be obtained by contacting A. Gallini, Dept. of Epidemiology, University Hospital Toulouse, 37 Allees Jules Guesde, 31 000, Toulouse, France. Additional authors for this research include E. Gombault-Datzenko, L. Carcaillon-Bentata, D. Fabre, F. Nourhashemi, S. Andrieu, A. Rachas and V. Gardette.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/ene.14256. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the European Journal of Neurology is: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA.

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