Soonchunhyang University Bucheon Hospital Researchers Publish New Studies and Findings in the Area of Pyogenic Liver Abscess (Anaerobe coverage is important for the prognosis of pyogenic liver abscess: A population-based study in Korea): Liver Diseases and Conditions – Pyogenic Liver Abscess

2022 APR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Daily News -- New study results on pyogenic liver abscess have been published. According to news reporting from Bucheon, South Korea, by NewsRx journalists, research stated, “Gram-negative bacteria such as Klebsiella pneumoniae and Escherichia coli are the most common cause of pyogenic liver abscess (PLA).We investigated whether the use of anaerobic-covering antibiotics is essential for the treatment of pyogenic liver abscess. We analyzed the Health Insurance Review and Assessment Service data in Korea between 2007 and 2017.”

Funders for this research include Soonchunhyang University Funder DOI: 10.13039/501100002560 Award: Korean Association for the Study of the Liver Funder DOI: 10.13039/501100016147 Award: Korean Liver Foundation Funder DOI: 10.13039/501100016148 Award:.

The news correspondents obtained a quote from the research from Soonchunhyang University Bucheon Hospital: “We classified PLA into two groups: a group using antibiotics that inhibited only aerobic strains (anaerobe (-) group) and a group using antibiotics that inhibited both aerobic and anaerobic strains (anaerobe (+) group). The primary outcome was the difference in in-hospital mortality between the two groups. During this period, a total of 30,690 PLA patients were obtained. There were 6733 patients in the anaerobe (-) group and 23,957 patients in the anaerobe (+) group. In-hospital mortality was significantly lower in the anaerobe (+) group than the anaerobe (-) group (7.9% vs. 15.6%, p < 0.001). In multivariate analysis, the use of anaerobic antibiotics reduced the in-hospital mortality by 42% (odds ratio 0.42, 95% confidence interval 0.38-0.46, p < 0.001) after adjusting for age and comorbidities. Furthermore, the improvement of in-hospital mortality was present regardless of the presence of cancer or diabetes.”

According to the news reporters, the research concluded: “The use of broad-spectrum empirical antibiotics covering anaerobic strains is important for the treatment of pyogenic liver abscess.”

For more information on this research see: Anaerobe coverage is important for the prognosis of pyogenic liver abscess: A population-based study in Korea. Journal of Infection and Public Health, 2022,15(4):425-432. (Journal of Infection and Public Health - https://www.journals.elsevier.com/journal-of-infection-and-public-health). The publisher for Journal of Infection and Public Health is Elsevier.

A free version of this journal article is available at https://doi.org/10.1016/j.jiph.2022.03.003.

Our news editors report that more information may be obtained by contacting Jun-Ho Myeong, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea. Additional authors for this research include Dae-Sung Kyoung, Min-Ae Park, Sang Gyune Kim, Young Seok Kim, Jeong-Ju Yoo, Min Jae Kim. Our reports deliver fact-based news of research and discoveries from around the world.