Recent Findings in Risk Management Described by K.T. Bogen and Colleagues (Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic…

Recent Findings in Risk Management Described by K.T. Bogen and Colleagues (Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic Endpoints Independently Triggered by Ultrasensitive Molecular Switches)

By a News Reporter-Staff News Editor at Insurance Weekly News -- Research findings on Risk Management are discussed in a new report. According to news reporting originating from Oakland, California, by VerticalNews editors, the research stated, "Crump's response in this issue to my critique of linear-no-threshold (LNT) default assumptions for noncancer and nongenotoxic cancer risks (Risk Analysis 2016; 36(3):589-604) is rebutted herein."

Our news editors obtained a quote from the research, "Crump maintains that distinguishing between a low-dose linear dose response and a threshold dose response on the basis of dose-response data is impossible even for endpoints involving increased cytotoxicity. My rebuttal relies on descriptions and specific illustrations of two well-characterized ultrasensitive molecular switches that govern two key cytoprotective responses to cellular stressheat shock response and antioxidant response element activation, respectivelyeach of which serve to suppress stress-induced apoptotic cell death unless overwhelmed."

According to the news editors, the research concluded: "Because detailed dose-response data for each endpoint is shown to be J- or inverted-J-shaped with high confidence, and because independent pathways can explain background rates of apoptosis, LNT assumptions for this cytotoxic endpoint are unwarranted, at least in some cases and perhaps generally."

For more information on this research see: Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic Endpoints Independently Triggered by Ultrasensitive Molecular Switches. Risk Analysis, 2017;37(10):1808-1816. Risk Analysis can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Risk Analysis - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1539-6924)

The news editors report that additional information may be obtained by contacting K.T. Bogen, Exponent Hlth Sci, Oakland, CA 94612, United States.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/risa.12813. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Oakland, California, United States, North and Central America, Risk Management, Risk and Prevention.

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