U.S. Patents Awarded to Inventors in Massachusetts (Sept. 28)

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ALEXANDRIA, Va., Sept. 28 -- The following federal patents were awarded to inventors in Massachusetts.

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ChemGenes Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- ChemGenes, Wilmington, Mass., has been assigned a patent (8,541,569) developed by Suresh C. Srivastava, Burlington, Mass., and Naveen P. Srivastava, Burlington, Mass., for "phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA."

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3' end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5'.fwdarw.3' direction, leading to very clean oligo synthesis that allows for the introduction of various modifications at the 3'-end cleanly and efficiently. Higher coupling efficiency per step have been observed during automated oligo synthesis with the reverse RNA amidites disclosed herein, resulting in a greater ability to achieve higher purity and produce very long oligonucleotides. The use of the reverse RNA phosphoramidites in the synthetic process of this invention leads to oligonucleotides free of N+1 species."

The patent application was filed on Feb. 19, 2010 (12/708,827). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,569.PN.&OS=PN/85,41,569&RS=PN/85,41,569

Written by Amal Ahmed; edited by Jaya Anand.

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Isis Pharmaceuticals Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Isis Pharmaceuticals, Carlsbad, Calif., has been assigned a patent (8,541,599) developed by five co-inventors for "supports for oligomer synthesis." The co-inventors are Vasulinga Ravikumar, Carlsbad, Calif., Muthiah Manoharan, Weston, Mass., Andrei P. Guzaev, Vista, Calif., Zhiwei Wang, Carlsbad, Calif., and Raju K. Kumar, San Marcos, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Universal linkers, their facile processes of manufacture and methods of using the same are provided."

The patent application was filed on March 7, 2012 (13/414,516). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,599.PN.&OS=PN/85,41,599&RS=PN/85,41,599

Written by Amal Ahmed; edited by Jaya Anand.

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Infinity Pharmaceuticals Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Infinity Pharmaceuticals, Cambridge, Mass., has been assigned a patent (8,541,581) developed by four co-inventors for "inhibitors of fatty acid amide hydrolase." The co-inventors are Alfredo C. Castro, Winchester, Mass., Catherine A. Evans, Somerville, Mass., Louis Grenier, Newton, Mass., and Michael J. Grogan, Winchester, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z.sup.1, Z.sup.2, X.sup.1, X.sup.2, X.sup.3, R.sup.1, R.sup.2, R.sup.3, R.sup.4, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention. ##STR00001##."

The patent application was filed on April 7, 2010 (13/263,324). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,581.PN.&OS=PN/85,41,581&RS=PN/85,41,581

Written by Amal Ahmed; edited by Jaya Anand.

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Harvard College, Life Technologies Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Harvard College, Cambridge, Mass., and Life Technologies, Carlsbad, Calif., have been assigned a patent (8,541,570) developed by four co-inventors for "methods and compositions for labeling nucleic acids." The co-inventors are Kyle R. Gee, Springfield, Ore., Brian Agnew, Eugene, Ore., Adrian Salic, Cambridge, Mass., and Timothy J. Mitchison, Brookline, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include a Staudinger ligation between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent comprising a substituted triarylphosphine attached to a label. Such methods do not require fixation and denaturation and therefore can be applied to the labeling of nucleic acid polymers in living cells and in organisms. Also provided are methods for measuring cellular proliferation. In these methods, the amount of label incorporated into the DNA is measured as an indication of cellular proliferation. The methods of the invention can be used in a wide variety of applications including clinical diagnosis of diseases and disorders in which cellular proliferation is involved, toxicity assays, and as a tool for the study of chromosomes' ultrastructures."

The patent application was filed on May 24, 2010 (12/785,999). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,570.PN.&OS=PN/85,41,570&RS=PN/85,41,570

Written by Amal Ahmed; edited by Jaya Anand.

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General Hospital Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- General Hospital, Boston, has been assigned a patent (8,541,484) developed by Jeeyoung Choi, Spartanburg, S.C., and Orhun K. Muratoglu, Cambridge, Mass., for PVA-PAA hydrogels.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-hydrogels, and cross-linked PVA-hydrogel-containing compositions also are disclosed herein."

The patent application was filed on April 24, 2008 (12/597,056). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,484.PN.&OS=PN/85,41,484&RS=PN/85,41,484

Written by Amal Ahmed; edited by Jaya Anand.

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Merch Sharp & Dohme Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Merch Sharp & Dohme, Rahway, N.J., has been assigned a patent (8,541,595) developed by Peter J. Manley, Harleysville, Pa., Kausik K. Nanda, Norristown, Pa., and B. Wesley Trotter, Newton Highlands, Mass., for "imidazoisoindole neuropeptide S receptor antagonists."

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is directed to imidazoisoindole compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved."

The patent application was filed on Nov. 3, 2009 (13/127,985). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,595.PN.&OS=PN/85,41,595&RS=PN/85,41,595

Written by Amal Ahmed; edited by Jaya Anand.

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Lockheed Martin Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Lockheed Martin, Bethesda, Md., has been assigned a patent (8,539,898) developed by Russell M. Sylvia, South Dartmouth, Mass., and Christopher R. Makuch, Fairhaven, Mass., for an "underwater vehicle with improved controls and modular payload."

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A system for enhancing control of an underwater vehicle, and providing a quick change modular payload section includes a motor configured to rotate an internally threaded member threadingly engaged with a threaded rod. Rotating the member creates linear motion of the threaded rod. A control rod connected to the threaded rod provides movement of a rudder or fin. The threaded rod and member are configured with threads having a fine pitch which maintains a stable position of the fins without needing to supply power to the motor for adjustments. The modular payload arrangement includes a bulkhead ring having L-shaped recesses that receive fasteners disposed on a central body section. The payload section may be fastened to the vehicle by pressing the payload section onto the central body such that the fasteners align with the recesses and turning the payload section to secure the payload section."

The patent application was filed on March 24, 2010 (12/730,675). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,539,898&OS=8,539,898&RS=8,539,898

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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University of Maryland Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- The University of Maryland, College Park, Md., has been assigned a patent (8,541,563) developed by five co-inventors for "plant wall degradative compounds and systems." The co-inventors are Larry Edmund Taylor, Lakewood, Colo., Ronald M. Weiner, Potomac, Md., Steven Wayne Hutcheson, Columbia, Md., Nathan A. Ekborg, Beverly, Mass., and Michael Howard, Annapolis, Md.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications."

The patent application was filed on May 7, 2012 (13/465,714). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,563.PN.&OS=PN/85,41,563&RS=PN/85,41,563

Written by Amal Ahmed; edited by Jaya Anand.

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Amgen, Biovitrum Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Amgen, Thousand Oaks, Calif., and Biovitrum, Stockholm, Sweden, have been assigned a patent (8,541,592) developed by 20 co-inventors for "inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1." The co-inventors are Martin Henriksson, Stockholm, Sweden, Evert Homan, Sollentuna, Sweden, Lars Johansson, Stockholm, Sweden, Jerk Vallgarda, Uppsala, Sweden, Meredith Williams, Singapore, Eric A. Bercot, Moorpark, Calif., Christopher H. Fotsch, Thousand Oaks, Calif., Aiwen Li, Westlake Village, Calif., Guolin Cai, Thousand Oaks, Calif., Randall W. Hungate, Camarillo, Calif., Chester Chenguang Yuan, Newbury Park, Calif., Christopher Tegley, Thousand Oaks, Calif., David J. St. Jean Jr., Camarillo, Calif., Nianhe Han, Thousand Oaks, Calif., Qi Huang, Moorpark, Calif., Qingyian Liu, Camarillo, Calif., Michael D. Bartberger, Sherman Oaks, Calif., George A. Moniz, Cambridge, Mass., Matthew J. Frizzle, Dundas, Canada, and Teresa L. Marshall, Stow, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-.beta.-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-.beta.-hydroxysteroid dehydrogenase type 1 enzyme."

The patent application was filed on Nov. 13, 2006 (11/598,238). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,592.PN.&OS=PN/85,41,592&RS=PN/85,41,592

Written by Amal Ahmed; edited by Jaya Anand.

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Merck Sharp & Dohme Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Merck Sharp & Dohme, Rahway, N.J., has been assigned a patent (8,541,572) developed by 21 co-inventors for "compounds for the treatment of inflammatory disorders." The co-inventors are Joseph A. Kozlowski, Princeton, N.J., Wensheng Yu, Edison, N.J., Michael K. C. Wong, Somerset, N.J., Seong Heon Kim, Livington, N.J., Ling Tong, Warren, N.J., Brian J. Lavey, New Providence, N.J., Bandarpalle B. Shankar, Branchburg, N.J., De-Yi Yang, Morris Plains, N.J., Robert Feltz, Washington, Pa., Aneta Maria Kosinski, South Amboy, N.J., Guowei Zhou, Somerset, N.J., Razia K. Rizvi, Bloomfield, N.J., Chaoyang Dai, Acton, Mass., Luke Fire, Cambridge, Mass., Vinay Girijavallabhan, Denville, N.J., Dansu Li, Reading, Mass., Janeta Popovici-Muller, Waltham, Mass., Judson E. Richard, Kittery, Maine, Kristin E. Rosner, Watertown, Mass., M. Arshad Siddiqui, Newton, Mass., and Liping Yang, Arlington, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF--or combinations thereof. ##STR00001##."

The patent application was filed on Nov. 9, 2009 (13/127,952). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,572.PN.&OS=PN/85,41,572&RS=PN/85,41,572

Written by Amal Ahmed; edited by Jaya Anand.

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Waters Technologies Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Waters Technologies, Milford, Mass., has been assigned a patent (8,539,819) developed by four co-inventors for a "pressure monitor optimization of fluid path utilization." The co-inventors are Theodore D. Ciolkosz, Plymouth, Mass., James E. Usowicz, Webster, Mass., Peyton C. Beals, Wrentham, Mass., and Russell Keene, Sudbury, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system."

The patent application was filed on March 9, 2012 (13/416,364). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,539,819&OS=8,539,819&RS=8,539,819

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Foster-Miller Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Foster-Miller, Waltham, Mass., has been assigned a patent (8,539,875) developed by five co-inventors for a protection system. The co-inventors are David J. Hoadley, Lexington, Mass., Robert Knochenhaur, Billerica, Mass., Thieu Truong, North Easton, Mass., Gary Anderson, Leominster, Mass., and Michael Farinella, Belmont, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A net deployment system which, in one example, includes lengthy housing with a channel therein, a net folded in the channel, a lengthy bladder fixed to the housing and in the channel behind the net, attachments between the net and the bladder, and at least one inflator charge for inflating the bladder to deploy the net out of the channel."

The patent application was filed on Aug. 28, 2012 (13/596,472). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,539,875&OS=8,539,875&RS=8,539,875

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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International Business Machines Assigned Patent for Business Practices Alignment Methods

ALEXANDRIA, Va., Sept. 28 -- International Business Machines, Armonk, N.Y., has been assigned a patent (8,543,409) developed by Michael Joseph Armano, North Andover, Mass., and Sara J. Moulton Reger, Scottsdale, Ariz., for a "business practices alignment methods." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method to align and effectively apply business practices or culture within the business units in one or more business entities is provided. In the first phase, a practices charter defining future state business practices is developed. A practices charter is developed from an initial set of differing alternatives statements regarding future business practices, in view of a right-versus-right spectrum. A practices charter is an output of the reconciliation of differing alternatives statements in right-versus-right spectrums. In a second phase, a practices charter is applied to hypothetical issues to develop realistic outcome narratives describing hypothetical situations and dilemmas. In a third phase, discrepancies between outcome narratives and a current state of business practice are identified, and a prioritized action program is developed to address identified discrepancies. Finally, progress is evaluated by utilizing outcome narratives to identify achievements and to target areas needing further improvement and additional actions." The patent application was filed on May 30, 2008 (12/130,379). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,409.PN.&OS=PN/8,543,409&RS=PN/8,543,409

Written by Kusum Sangma; edited by Anand Kumar.

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Casella Waste Systems Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Casella Waste Systems, Rutland, Vt., has been assigned a patent (8,542,121) developed by four co-inventors for "systems and methods for identifying and collecting banned waste." The co-inventors are Dominic Maruca, Holliston, Mass., Jerry Leone, Victor, N.Y., Nancy Edwards Cronin, Jericho, Vt., and John A. Kintzer, Waterbury, Vt.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Systems and methods for authorizing a waste item to be removed from a site. In one embodiment, a waste collection vehicle includes a reader configured to obtain identification information from an identification tag associated with the waste item. A transceiver associated with the vehicle is configured to: receive the identification information from the reader, wirelessly transmit the identification information to a remote computer for processing, and wirelessly receive an indication of whether the waste item should be collected and removed by the waste collection. The received indication is based on at least one hazardous characteristic associated with the identified waste item, a determination that the waste collection vehicle is authorized to collect the waste item having the at least one hazardous characteristic, and a determination that a driver of the waste collection vehicle is authorized to collect the waste item having the at least one hazardous characteristic."

The patent application was filed on July 22, 2011 (13/189,200). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8542121.PN.&OS=PN/8542121&RS=PN/8542121

Written by Sudarshan Harpal; edited by Jaya Anand.

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Bluefin Labs Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Bluefin Labs, Cambridge, Mass., has been assigned a patent (8,543,454) developed by Michael Ben Fleischman, Somerville, Mass., Deb Kumar Roy, Arlington, Mass., and Jeremy Rishel, Maynard, Mass., for "generating audience response metrics and ratings from social interest in time-based media." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Social media content items are mapped to relevant time-based media events. These mappings are used as the basis for calculating metrics based upon the mappings, and ratings of the time-based media there from. Audience response metrics (ARMs) are calculated from the mappings, which provide an indication of audience engagement or response. In addition, ARMs provide information about the virality, depth, and breadth of the response by the viewing audience. The calculated metrics are stored and are used to generate ratings for the time-based media. The ratings may be published in whole or in part, e.g., as part of a ratings system." The patent application was filed on Feb. 18, 2011 (13/030,940). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,454.PN.&OS=PN/8,543,454&RS=PN/8,543,454

Written by Kusum Sangma; edited by Anand Kumar.

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Fresenius Medical Care Holdings Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Fresenius Medical Care Holdings, Waltham, Mass., has been assigned a patent (8,543,420) developed by four co-inventors for a "patient-specific content delivery methods and systems." The co-inventors are Kristin Darby, Boston, Ravi Kalathil, Waltham, Mass., Kurt Littlefield, Derry, N.H., and Maria Burke, Waxhaw, N.C. The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods and systems for delivery of digital data in connection with medical treatment and patient care include detecting a current medical condition of a patient receiving medical treatment and delivering electronic informational data to the patient over a network. The informational data can be selected for delivery based on the current medical condition of the patient. The informational data can includes a plurality of informational data content options, and the patient can choose one or more of the informational data content options for delivery to the patient over the network. The chosen content can be displayed to the patient on a digital data display device, such as a touch screen monitor." The patent application was filed on Sept. 18, 2008 (12/233,126). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,420.PN.&OS=PN/8,543,420&RS=PN/8,543,420 Written by Kusum Sangma; edited by Anand Kumar.

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International Business Machines Assigned Patent for Methods, Systems, and Computer Program Products for Providing an Information Storage Management System

ALEXANDRIA, Va., Sept. 28 -- International Business Machines, Armonk, N.Y., has been assigned a patent (8,543,419) developed by Paul Reed, Brookline, Mass., for "methods, systems, and computer program products for providing an information storage management system." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods, systems, and computer program products for providing a policy-based information storage management system for digital assets are provided. The storage management system includes multiple physical storage subsystems, each with deterministic storage characteristics. A method includes receiving a data item related to a subject and looking up a record for the subject. The record identifies corresponding digital assets that are stored in the storage subsystems. The method also includes applying a policy to the corresponding digital assets based upon the data item. The method further includes determining a subset of the digital assets in the record that are relevant to the data item. The relevance determination is made in response to application of the policy. The method also includes migrating the relevant digital assets to at least one designated storage subsystem, based upon corresponding storage characteristics, for expediting access to the relevant digital assets." The patent application was filed on Dec. 20, 2007 (11/961,552). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,419.PN.&OS=PN/8,543,419&RS=PN/8,543,419

Written by Kusum Sangma; edited by Anand Kumar.

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Intel Assigned Patent for Apparatus, System, and Method for Voltage Swing and Duty Cycle Adjustment

ALEXANDRIA, Va., Sept. 28 -- Intel, Santa Clara, Calif., has been assigned a patent (8,542,046) developed by six co-inventors for an "apparatus, system, and method for voltage swing and duty cycle adjustment." The co-inventors are Eduard Roytman, Newton Centre, Mass., Jian Xu, Westborough, Mass., Rahul R. Shah, Marlborough, Mass., Kambiz R. Munshi, Shrewsbury, Mass., Ronald L. Bedard, Westminster, Mass., and Mahalingam Nagarajan, Grafton, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Described herein are an apparatus, system, and method for compensating voltage swing and duty cycle of a signal on an input-output (I/O) pad of a processor by adjusting the voltage swing and duty cycle of the signal. The apparatus comprises a driver to transmit a signal on an I/O pad, the signal on the I/O pad having a voltage swing and a duty cycle; and an adjustment unit, coupled to the driver, to receive the signal from the I/O pad transmitted by the driver and to generate voltage swing and duty cycle control signals for adjusting the voltage swing and duty cycle of the signal on the I/O pad respectively. Described herein is also an analog-to-digital (A2D) converter for measuring and/or calibrating various signal attributes including current, voltage, and time."

The patent application was filed on May 4, 2011 (13/100,669). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8542046.PN.&OS=PN/8542046&RS=PN/8542046

Written by Sudarshan Harpal; edited by Jaya Anand.

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Aurus Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Aurus, Boston, has been assigned a patent (8,543,461) developed by Rahul Mutha, Norwood, Mass., for "systems and methods for removing point of sale processing from PCI scope." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The methods and systems described herein provide for processing payments at a retail location whose infrastructure has been significantly removed from PCI scope. A request for processing payments may be sent from a point of sale lane to a back office server in communication with a credit card terminal. A user may use the credit card terminal to enter in secure payment information which is securely transmitted to a remote authorization service for authorization. Through this method, the credit card terminal and sensitive payment information may be securely isolated from the remaining infrastructure at the retail location." The patent application was filed on May 31, 2012 (13/485,490). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,461.PN.&OS=PN/8,543,461&RS=PN/8,543,461

Written by Kusum Sangma; edited by Anand Kumar.

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STB Enterprises Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- STB Enterprises, Coralville, Iowa, has been assigned a patent (8,543,457) developed by William E. Staib, Coralville, Iowa, and Dean Scott Blodgett, Tewksbury, Mass., for a "method for dynamically building documents based on observed internet activity." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method of collecting data from pages viewed by a user of at least one web site, comprises receiving from at least one activity message reporter a plurality of access reports wherein an access report includes content from at least one web page of the at least one web site. Thereafter the method accumulates the received access reports, and formats content from the received access reports in accordance with a document template." The patent application was filed on May 23, 2006 (11/438,976). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,457.PN.&OS=PN/8,543,457&RS=PN/8,543,457

Written by Kusum Sangma; edited by Anand Kumar.

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Google Assigned Patent for Competitive Availability Tools

ALEXANDRIA, Va., Sept. 28 -- Google, Mountain View, Calif., has been assigned a patent (8,543,432) developed by Jeremy Wertheimer, Brookline, Mass., and Carl G. DeMarcken, Arlington, Mass., for a competitive availability tools. The abstract of the patent published by the U.S. Patent and Trademark Office states: "A competitive, availability prediction system for predicting relative, competitive availability of seating on an airline flight is described. The system includes an availability predictor that predicts seating availability on a competitive flight, an availability system that produces an actual availability response for a flight and decision logic that compares the predicted answer from the availability predictor and the potential answer from the availability system to establish a decision with respect to actual availability." The patent application was filed on Feb. 1, 2011 (13/018,530). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,432.PN.&OS=PN/8,543,432&RS=PN/8,543,432

Written by Kusum Sangma; edited by Anand Kumar.

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Hartford Fire Insurance Assigned Patent for System and Method for Generating and Providing a Simplified Voluntary Disability Product

ALEXANDRIA, Va., Sept. 28 -- Hartford Fire Insurance, Hartford, Conn., has been assigned a patent (8,543,426) developed by nine co-inventors for a "system and method for generating and providing a simplified voluntary disability product." The co-inventors are Mark P. Belliveau, Windsor, Conn., Barbara S. Campbell, Longwood, Fla., Joan Crandall, Bloomfield, Conn., Susan Duncan, Canton, Conn., Kim Johnson, Avon, Conn., Lori A. Minchoff, Fiskdale, Mass., Will Perez, South Windsor, Conn., Alyce Roberts, Rocky Hill, Conn., and Christine T. Vujs, North Granby, Conn. The abstract of the patent published by the U.S. Patent and Trademark Office states: "Disclosed is a novel disability insurance product that provides a benefit to the purchaser. The insurance product comprises a disability insurance product which offers coverage for a predetermined limited period of time. If at the end of the predetermined period of time the insured individual is still disabled according to the terms of the insurance product, the insurance provider will pay a lump sum benefit." The patent application was filed on Dec. 21, 2007 (12/004,886). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,543,426.PN.&OS=PN/8,543,426&RS=PN/8,543,426 Written by Kusum Sangma; edited by Anand Kumar.

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Waters Technologies Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Waters Technologies, Milford, Mass., has been assigned a patent (8,539,982) developed by Russell Keene, Sudbury, Mass., and David R. Friswell, Upton, Mass., for a "flow through isolation valve for high pressure fluid."

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A flow through isolation valve having a stationary member; a movable member, with a surface of the stationary member interfacing with a surface of the movable member; and at least one pin isolation valve. The pin isolation valve has a flow through internal conduit and is movable so that the internal conduit can fluidically communicate with at least one blank opening in the movable member and with a flow through internal conduit in the movable member. Movement is by rotation, linear or curvilinear translation. At least one pin isolation valve is fluidically coupled typically to a sample loop of a face seal valve, or to a pump supplying high pressure liquid to or to a column discharging liquid from a face seal valve of a high pressure liquid chromatography (HPLC) system or directly to the face seal valve."

The patent application was filed on March 2, 2005 (10/598,072). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,539,982&OS=8,539,982&RS=8,539,982

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Vertex Pharmaceuticals Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Vertex Pharmaceuticals, Cambridge, Mass., has been assigned a patent (8,541,025) developed by five co-inventors for "co-crystals and pharmaceutical formulations comprising the same." The co-inventors are Eleni Dokou, Cambridge, Mass., Rahela Gasparac, Watertown, Mass., Dragutin Knezic, Watertown, Mass., Billie J. Kline, Kingston, Mass., and Valdas Jurkauskas, Cambridge, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "An immediate release formulation of an active ingredient."

The patent application was filed on Feb. 24, 2011 (13/034,039). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,541,025&OS=8,541,025&RS=8,541,025

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Cnano Technology Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Cnano Technology, San Francisco, has been assigned a patent (8,540,902) developed by six co-inventors for a "carbon nanotube based pastes." The co-inventors are Caihong Xing, Beijing, Jianfeng Wang, Beijing, Zhaojie Wei, Beijing, Jun Ma, Irvine, Calif., Ching-Jung Tsai, Beijing, and Li; Qi Tsai, Marlborough, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Carbon-nanotube based pastes and methods for making and using the same are disclosed. Carbon nanotubes are dispersed via milling; resultant paste has Hegman scale of greater than 7. The pastes can be used as electro-conductivity enhancement in electronic devices such as batteries, capacitors, electrodes or other devices needing high conductivity paste."

The patent application was filed on Jan. 13, 2011 (13/006,266). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,540,902&OS=8,540,902&RS=8,540,902

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Tesla Motors Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Tesla Motors, Palo Alto, Calif., has been assigned a patent (8,539,990) developed by six co-inventors for a "vehicle port door with wirelessly actuated unlatching assembly." The co-inventors are Joshua Willard Ferguson, Alameda, Calif., Daryl Zalan, San Francisco, Andrew Dai, Acton, Mass., Troy Adam Nergaard, San Francisco, Nicholas Robert Kalayjian, San Carlos, Calif., and Scott Ira Kohn, Redwood City, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A port door unlatching system is provided that may be used to open the door covering the charge port of an electric vehicle, or the door covering the fuel filler port of a conventional vehicle. The system includes a fuel delivery subsystem with a fuel coupler (e.g., a charging connector or a gas nozzle) designed to transfer fuel from the source to the vehicle via the vehicle's fuel port. The fuel coupler includes a switch that when toggled, causes a control signal to be wirelessly transmitted over a short distance. Upon receipt of the control signal by a receiver integrated into a vehicle that is in close proximity to the fuel port, an unlatching actuator within the vehicle unlatches the port door, thereby allowing it to open and provide port access."

The patent application was filed on June 6, 2012 (13/489,617). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,539,990&OS=8,539,990&RS=8,539,990

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Massachusetts Institute of Technology Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Massachusetts Institute of Technology, Cambridge, Mass., has been assigned a patent (8,541,810) developed by six co-inventors for a "blue light emitting semiconductor nanocrystal materials." The co-inventors are Jonathan S. Steckel, Cambridge, Mass., John P. Zimmer, Cambridge, Mass., Seth Coe-Sullivan, Belmont, Mass., Nathan E. Stott, Albuquerque, N.M., Vladimir Bulovi , Lexington, Mass., and Moungi G. Bawendi, Cambridge, Mass. The abstract of the patent published by the U.S. Patent and Trademark Office states: "A semiconductor nanocrystal includes a core including a first semiconductor material and an overcoating including a second semiconductor material. A monodisperse population of the nanocrystals emits blue light over a narrow range of wavelengths with a high quantum efficiency." The patent application was filed on Nov. 16, 2011 (13/297,968). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,541,810.PN.&OS=PN/8,541,810&RS=PN/8,541,810 Written by Kusum Sangma; edited by Anand Kumar.

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Oracle International Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Oracle International, Redwood Shores, Calif., has been assigned a patent (8,543,535) developed by five co-inventors for a "generation of star schemas from snowflake schemas containing a large number of dimensions." The co-inventors are Samir Satpathy, Bangalore, India, Alextair Dominico Mascarenhas, Redwood Shores, Calif., Harvard Jun-Hua Pan, Allston, Mass., Kenneth Khiaw Hong Eng, Redwood Shores, Calif., and Ladislav Kovac, Ottawa.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "An aspect of the present invention simplifies generating a star schema from a snowflake schema. In an embodiment, a user first specifies fact tables to be included in a star schema, and a synchronization tool inspects the snowflake schema to determine the dimension tables linked to the specified fact tables. The determined dimension tables are included in the star schema sought to be generated."

The patent application was filed on Feb. 24, 2010 (12/711,269). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,543,535&OS=8,543,535&RS=8,543,535

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Schlumberger Technology Assigned Patent for Apparatus and Method for Treating a Subterranean Formation Using Diversion

ALEXANDRIA, Va., Sept. 28 -- Schlumberger Technology, Sugar Land, Texas, has been assigned a patent (8,540,015) developed by five co-inventors for an "apparatus and method for treating a subterranean formation using diversion." The co-inventors are Murat Ocalan, Boston, Francois M. Auzerais, Boston, Partha Ganguly, Sugar Land, Texas, Agathe Robisson, Cambridge, Mass., and Jahir Pabon, Newton, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Apparatus and method comprising a plurality of particles which are magnetically attracted to one another in response to exposure to a magnetic field, and which maintain attraction to one another after removal of the magnetic field, the attraction being disabled when the particles are demagnetized, whereby the particles operate to alter the rheological properties of a fluid in which the particles are mixed when the attraction is enabled or disabled is disclosed."

The patent application was filed on Sept. 24, 2012 (13/625,670). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,540,015&OS=8,540,015&RS=8,540,015

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Oracle International Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Oracle International, Redwood Shores, Calif., has been assigned a patent (8,542,104) developed by Marc H. Horowitz, Cambridge, Mass., for a "RFID edge server having a programmable logic controller API."

The abstract of the patent published by the U.S. Patent and Trademark Office states: "An RFID edge server is adapted to receive RFID data from RFID readers. The RFID edge server can have a PLC API to allow the RFID edge server to control and receive data from devices."

The patent application was filed on Feb. 25, 2008 (12/036,898). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8542104.PN.&OS=PN/8542104&RS=PN/8542104

Written by Sudarshan Harpal; edited by Jaya Anand.

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Agenus Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Agenus, Lexington, Mass., has been assigned a patent (8,541,002) developed by six co-inventors for a "vaccine for treatment and prevention of herpes simplex virus infection." The co-inventors are Alemseged Truneh, Sudbury, Mass., Daniel L. Levey, Boston, Xiaoyan Mo, Boxborough, Mass., Kenneth P. Leclair, Needham, Mass., Ramesh S. Kashi, Warren, N.J., and Chuanliang Liu, King of Prussia, Pa.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions comprising complexes of antigenic peptides and adjuvants that can activate an immune response against herpes viruses. The invention also provides methods of making the antigenic peptides and complexes of antigenic peptides and adjuvants. Methods of use of the pharmaceutical compositions are also provided."

The patent application was filed on Sept. 13, 2004 (10/571,716). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,541,002&OS=8,541,002&RS=8,541,002

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Kraft Foods Group Brands Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Kraft Foods Group Brands, Northfield, Ill., has been assigned a patent (8,541,038) developed by 10 co-inventors for a "food package for segregating ingredients of a multi-component food product." The co-inventors are Daniel R. Feldmeier, Waunakee, Wis., Metty Poei, Wilmette, Ill., Mary Amanda Lamp, Waunakee, Wis., Brian Patrick Lawless, Hawthorn Woods, Ill., Paul Edward Doll, Madison, Wis., Edward L. Dickinson, Littleton, Mass., Patsy Anthony Coppola, Bedford, Mass., Stephen K. Guerrera, Holliston, Mass., David J. Smith, Needham, Mass., and Gregorio Ramon Maramba Abesames, North Andover, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A food package for segregating ingredients of a multi-component food product, such as the multiple components of a sandwich, the package comprising an outer container to house a first food component and at least one flexible envelope or barrier film layer that encloses at least one intermediate food component allowing for separation of the intermediate food component during extended periods of storage and prior to opening the product. A method for opening the package comprises applying a pulling force to an externally located protruding end portion of the envelope, such that the envelope peels apart and separates into ruptured layers that are pulled out of the food product and out of the outer container by the continual pulling force from the protruding end portion."

The patent application was filed on Nov. 18, 2008 (12/273,032). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,541,038&OS=8,541,038&RS=8,541,038

Written by Satyaban Rath; edited by Hemanta Panigrahi.

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Cognex Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Cognex, Natick, Mass., has been assigned a patent (8,542,281) developed by E. John McGarry, La Jolla, Calif., and William M. Silver, Weston, Mass., for a "system and method for acquiring a still image from a moving image."

The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention provides a system and method captures a moving image of a scene that can be more readily de-blurred as compared to images captured through the above-referenced and other known methods operating on an equivalent exposure-time interval. Rather than stopping and starting the integration of light measurement during the exposure-time interval, photo-generated current is switched between multiple charge storage sites in accordance with a temporal switching pattern that optimizes the conditioning of the solution to the inverse blur transform. By switching the image intensity signal between storage sites all of the light energy available during the exposure-time interval is transduced to electronic charge and captured to form a temporally decomposed representation of the moving image. As compared to related methods that discard approximately half of the image intensity signal available over an equivalent exposure-time interval, such a temporally decomposed image is a far more complete representation of the moving image and more effectively de-blurred using simple linear de-convolution techniques."

The patent application was filed on Sept. 14, 2009 (12/559,467). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8542281.PN.&OS=PN/8542281&RS=PN/8542281

Written by Sudarshan Harpal; edited by Jaya Anand.

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Agere Systems Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Agere Systems, Allentown, Pa., has been assigned a patent (8,542,031) developed by four co-inventors for a "method and apparatus for regulating a power supply of an integrated circuit." The co-inventors are Kouros Azimi, Center Valley, Pa., Mohammad S. Mobin, Orefield, Pa., Gregory W. Sheets, Boxborough, Mass., and Lane A. Smith, Easton, Pa.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Disclosed is a circuit for adjusting a voltage supplied to an IC by a power supply circuit that produces a regulated-output voltage based on an output-control signal generated by a resistive voltage divider. The circuit includes a PVT detector configured to generate an interface control signal and an interface circuit (i) connected to PVT detector and to the resistive voltage divider and (ii) configured to adjust its resistance in response to the interface control signal. Adjusting the resistance of the interface circuit causes the voltage of the output-control signal to be adjusted, thus causing the power supply circuit to adjust the regulated output voltage."

The patent application was filed on Nov. 28, 2011 (13/304,759). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8542031.PN.&OS=PN/8542031&RS=PN/8542031

Written by Sudarshan Harpal; edited by Jaya Anand.

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Amgen Assigned Patent

ALEXANDRIA, Va., Sept. 28 -- Amgen, Thousand Oaks, Calif., has been assigned a patent (8,541,593) developed by seven co-inventors for a "process for making substituted 2-amino-thiazolones." The co-inventors are George A. Moniz, Cambridge, Mass., Matthew J. Frizzle, Dundas, Canada, Charles Bernard, Moorpark, Calif., Michael Martinelli, San Diego, Margaret M. Faul, Newbury Park, Calif., Roger Nani, Bronx, N.Y., and Jay Larrow, Wakefield, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein."

The patent application was filed on June 20, 2008 (12/665,405). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=85,41,593.PN.&OS=PN/85,41,593&RS=PN/85,41,593

Written by Amal Ahmed; edited by Jaya Anand.

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