2021 ESHG Report (PDF)

At Centene, we understand that our diverse workforce enhances our ability to provide innovative and thoughtful health solutions for our members. Since our founding, we've held the belief that a diverse, equitable, and inclusive workforce brings out the best in all of us, and our leadership, organization, and culture reflect this core value. Of our domestic workforce, 76% are women, with 65% of supervisory positions held by women. Forty-eight percent of our employees identify as people of color, and 10% of our workforce identify as having a disability.

As a leader in government-sponsored healthcare, Centene is in a unique position to address the environmental, social, and health barriers that impact our most vulnerable populations. Supported by a culture of sound corporate governance, our commitment to the secure and responsible management of information and data is strong. We remain a solutions-oriented partner committed to addressing some of the world's most complex and systemic issues. Centene looks forward to sharing more about our progress and our commitment to delivering long-term value through our ESHG initiatives.

SARAH LONDON

Vice Chairman

LETTER FROM THE ACTING CHAIRMAN OF THE BOARD

Centene's focus on environmental, social, and corporate governance (ESG) issues is foundational to our mission as a company. Indeed, as chair of the Centene Board of Directors' Environmental and Social Responsibility Committee, I see firsthand the work being done to ensure that issues of environmental and social importance are centered in the development of our organization's strategic plan.

ABOUT CENTENE

Centene offers a comprehensive portfolio of health solutions to more than 26 million members across the U.S. and in our international markets. We believe in a local approach to delivering culturally sensitive healthcare that helps our members get healthy and stay healthy. As the industry leader in government-sponsored healthcare, we envision a future where individuals, families, communities, and healthcare are connected in ways never before imagined across the globe. At Centene, we are transforming the health of the community, one person at a time.

This report underlines the emphasis Centene places on ESG topics, including our fundamental focus on health, specifically healthcare access, quality, and affordability, which are central to supporting Centene's purpose and to ensuring the best possible health outcomes for those we serve.

Centene, which has been a member of the World Economic Forum for more than a decade, has long been at the forefront of the conversation about how social and environmental factors can impact health and healthcare access. The same is true around issues of diversity, equity, and inclusion. They have been keys to not only growing a diverse workforce and leadership but also in how we think about improving the health of the members we serve.

Centene has been selected as one of FORTUNE's World's Most Admired Companies® for the third consecutive year in the Insurance and Managed Care industry category. Senior executives, directors, and analysts rated enterprises within their own industries and evaluated them on nine criteria, from investment value and quality of management and products to social responsibility and ability to attract talent.

The Human Rights Campaign recognizes companies that have continued to advance vital workplace protections for LGBTQ+ employees around the world. Centene is among companies that achieved a top score for LGBTQ+- inclusive workplace policies in 2021.

As Acting Chairman of the Board of Centene, I am proud of the information highlighted in this report and the story it tells about the organization's positive impact on environmental, social, health, and governance issues - for our members and for the communities we serve.

JAMES DALLAS

Centene is on DiversityInc's 2021 list of the nation's top companies that hire, retain, and promote women, minorities, people with disabilities, LGBTQ+ employees, and veterans. The DiversityInc survey is the most comprehensive, data-driven diversity and inclusion analysis of some of the largest U.S. employers.

Centene has been included in Bloomberg's 2021 Gender-Equality Index (GEI), which lists companies recognized as global leaders in advancing women in the workplace. The GEI is designed to spotlight companies that have made strong commitments to gender equality through policy development, representation, and transparency.

Acting Chairman of the Board

2 Letter from the Acting Chairman of the Board

From FORTUNE, ©2022 FORTUNE Media IP Limited. All rights reserved. Used under license. FORTUNE and FORTUNE World's Most Admired Companies are registered trademarks of FORTUNE Media IP Limited and are used under license. FORTUNE is not affiliated with, and does not endorse the products or services of, Centene Corporation.

ENVIRONMENTAL, SOCIAL,HEALTH,AND GOVERNANCEFRAMEWORK

Since its founding as a single local healthcare plan in 1984, Centene has been focused on the health of the communities we serve. In alignment with our purpose of transforming the health of the community, one person at a time, we continue to center around the principles upon which our company was founded: focus on the individual, commitment to whole health, and active local involvement. These pillars shape our focus on the environment, the health and social well-being

of our communities, and our culture of ethics and governance.

At Centene, we include "Health" as a key component of our Environmental, Social, and Governance (ESG) strategy. Our ESHG strategic framework expresses Centene's commitments to Protect Our Planet, Serve Our Communities, Cultivate Healthier Lives, and Live Our Values, while identifying 16 key business areas essential to our success.

ESG ASSESSMENT

In 2020, Centene completed an ESG assessment to prioritize our ESHG topics, which included industry and peer group analysis, as well as executive interviews, while taking care to align our approach with our business strategy and long-term planning. The topics identified represent the areas where we believe we can make the most meaningful impact on environmental, social, and health issues, as well as our governance around those topics. In 2021, we published comprehensive information on our corporate website that centers on our ESG commitments. This information can be found at https://www.centene.com/why-were-different/corporate-sustainability.htmlandhttps://investors.centene.com/esg.

Through continuous improvement efforts, two of our topics have been adapted to better recognize Centene's current activities. As conversations on social justice resonated across the U.S. during the last two years, we have continued to focus on advancing diversity, equity, and inclusion across our business. As such, we have updated the name of this area from Diversity and Inclusion to Diversity, Equity and Inclusion in order to more accurately reflect the scope of this critical work. Additionally, we updated our Volunteerism topic to Community Engagement to reflect the impact our employees make through community service to nonprofit partners and by performing net positive actions that benefit society as a whole.

STAKEHOLDER ENGAGEMENT

Centene engages with a diverse group of stakeholders throughout the year to inform and execute our ESHG strategy.

Notable Themes in This Year's Report:

• Throughout the report, we have highlighted the relevant ESHG topics for each section by using the associated icons above.
• As our value chain has a meaningful impact on advancing our ESHG goals, we have added more information regarding our supply chain, including the supply chain process, risk management, and linkages to our ESHG topics and strategy.
• In this year's report, we identify numerous ways in which we are furthering achievement of the United Nations Sustainable Development Goals (UN SDGs) and are excited to communicate these to our audience.

The period of coverage for this report is January 1 through December 31, 2021, and performance data includes combined data for Centene Corporation and its subsidiaries unless otherwise noted.

Stockholders:

We engage with our stockholders via healthcare investor conferences, investor days, our Annual Review, 10-K, and annual meeting of stockholders in order to ensure we focus our ESHG efforts appropriately and increase transparency in reporting.

Employees:

Centene recently began the process of engaging our employees through the creation of an Environmental Employee Engagement Group (EEEG) Steering Committee. The EEEG Steering Committee has developed programming for 2022 to promote employee awareness, provide employee education, and support community engagement on environmental sustainability issues.

Policy makers:

Centene participates in public policy activities that have the potential to improve the access and delivery of healthcare, and affect our business, employees, and the communities in which we operate.

Suppliers:

We engage with our suppliers throughout the procurement process to ensure adequate data privacy and protection protocols are in place to safeguard data. We have also recently enhanced our Request for Proposal and Master Service Agreement to include language requiring diverse subcontractor reporting. Planning is underway to implement more formalized surveys to assess our supply chain's sustainability risks and measures.

4 ESHG Framework

BOARD OF DIRECTORS

Michael F. Neidorff

Chief Executive Officer

Sarah M. London

Vice Chairman, Centene Board of Directors

Orlando Ayala*

Retired Chairman and Corporate Vice President of Emerging Businesses for Microsoft Corporation

Jessica l. Blume

Retired Vice Chairman of Deloitte LLP

Kenneth Burdick

Retired Executive Vice President of

Products and Markets of Centene

Corporation; Former Chief Executive

Officer of WellCare Health Plans, Inc.

Christopher Coughlin

Former Executive Vice President and

Chief Financial Officer of Tyco

International, Ltd.

H. James Dallas*

Acting Chairman of Centene

Corporation; Retired Senior Vice

President and Chief Information Officer

of Medtronic

Wayne DeVeydt

Executive Chairman of the Board of Surgery Partners, Inc.

Frederick H. Eppinger*

President and Chief Executive Officer of Stewart Title Guaranty Company

Richard A. Gephardt*

Chief Executive Officer and President of

Gephardt Group, LLC; Former Majority

Leader of the U.S. House of

Representatives

Leslie V. Norwalk*

Strategic Counsel to Epstein Becker & Green, P.C., EBG Advisors, Inc. and National Health Advisors

Lori J. Robinson*

Retired United States Air Force General

Theodore Samuels*

Retired President of Capital Guardian Trust Company

William Trubeck

Retired Chief Financial Officer, Director,

and Executive Vice President of YRC

Worldwide; Retired Executive Vice

President and Chief Financial Officer of

H&R Block

A GLOBAL VISION

Centene actively partners with international organizations including the United Nations and the World Economic Forum to help the world meet increasingly complex and interrelated challenges. We recognize that participating in global initiatives is critical to our mission to transform the health of our local communities. This includes our support of the World Economic Forum's Global Healthcare Initiatives and its Young Global Leaders program. Senior Vice President and Chief Operating Officer of International Arvan Chan was selected as one of the 2021 honorees to mobilize other leaders and accelerate impact. This program seeks to bring together exceptional civic and business innovators, entrepreneurs, technology pioneers, educators, and more, with a common goal of creating a more inclusive and sustainable future.

Centene Corporation is a participant in the United Nations Global Compact (UNGC), which promulgates a set of 10 principles focused on the areas of human rights, labor, environment, and anti-corruption. We are committed to embodying these principles and have published a report on our progress at the following link: https://www.centene.com/content/dam/centenedotcom/documents/UN-Global-Compact-COP-Index-2021.pdf

Centene is also a signatory to the UN Women's Empowerment Principles, which offer guidance to businesses on how to promote gender equality and women's empowerment in the workplace,

*Member of the Environmental and Social Responsibility Committee

marketplace, and community. Chief Administrative Officer Shannon Bagley spoke at the 2021 Reykjavík Global Forum, and Regional Vice President of Diversity, Equity and Inclusion Erika

CENTENE'S ESHG LEADERSHIP

Centene's multifaceted approach to oversight of sustainability matters includes oversight provided by the Environmental and Social Responsibility Committee of Centene's Board of Directors, chaired by James Dallas, with Orlando Ayala, Frederick H. Eppinger, Richard A. Gephardt,

Leslie V. Norwalk, Lori J. Robinson, and Theodore Samuels serving as committee members.

Management Oversight Committee (MOC)

BOARD OF DIRECTORS

Environmental and

Social Responsibility

Committee

MANAGEMENT OVERSIGHT COMMITTEE

McConduit is a member of both the World Economic Forum Community of Chief Diversity and Inclusion Officers and the World 50 I&D Impact Community.

Centene is proud to be one of the 16 founding signatories to the Ethical Principles in Health Care (EPiHC), established in 2019 by the International Finance Corporation and the World Bank. Currently, over 175 signatories support the EPiHC, consisting of 10 principles set forth to help the private sector of developing countries build transparent and resilient operating systems that meet the highest ethical standards.

The MOC is a cross-functional governance group chaired by the CEO and composed of members of the executive leadership team. The MOC assists the board in its oversight responsibilities for risk management and oversees the process used to identify, assess, respond to, and report on risk issues, including climate-related and environmental issues.

UNITED

NATIONS SUSTAINABLE DEVELOPMENT GOALS

In 2016, the United Nations presented a set of Sustainable Development Goals (SDGs) that exemplify a shared global vision to transform the world by ending poverty, rescuing the planet, and establishing peace and prosperity, now and into the future. The following goals closely align with Centene's purpose and serve as a cornerstone of our ESHG strategic framework. For further information on SDGs, please see page 25.

ENVIRONMENTAL, SOCIAL, HEALTH, AND GOVERNANCE WORK GROUP

In 2020, Centene, established an internal work group composed of senior leadership representatives from both corporate functional areas and business units to advance Centene's ESHG strategy.

6 ESHG Framework