Allena Pharmaceuticals and Health Advances Present Analysis of Recurrent Kidney Stone Disease at the Academy of Managed Care Pharmacy Nexus Conference
“Although kidney stones are common in
Study Summary and Key Findings:
- Published literature, national procedure databases and fee schedules, insurance claims, and clinician interviews were used to create a Markov Model that describes the epidemiology and economics of calcium kidney stone disease.
- Based on this analysis, an estimated 17.8 million patients have been affected by calcium kidney stones, with 3.1 million predicted to experience stone episodes in 2016.
- Recurrent kidney stone disease patients represent 65% of all patients experiencing calcium kidney stones and are responsible for over 80% of the direct medical costs associated with treatment of calcium kidney stones.
- Patients with fast recurring kidney stone episodes represent a fraction of the patient population, but account for disproportionate associated healthcare costs, due to the frequency of episodes and probability of recurrence.
- In total, the 2016 direct medical cost of calcium kidney stones was estimated to be approximately
$23.3 billion , and is expected to grow to$70 billion by 2035.
“Recurrent kidney stone disease is a significant healthcare problem that impacts patients across demographic groups. Kidney stone patients often experience significant morbidity, intense pain, and a requirement for interventional procedures,” said
About Hyperoxaluria and ALLN-177
Hyperoxaluria is a condition resulting from high oxalate levels in the urine due to either hyper-absorption of oxalate from the diet (secondary) or from overproduction of oxalate by the liver due to a genetic defect (primary). Oxalate is a terminal metabolite that cannot be further degraded by humans and is primarily excreted by the kidneys. Hyperoxaluria can initially cause the development of kidney stones, and may also lead to kidney damage (nephrocalcinosis), chronic kidney disease, end-stage renal disease and dialysis. Calcium oxalate is the most common constituent of kidney stones. There are currently no approved pharmacologic treatments for hyperoxaluria.
ALLN-177 is an orally-administered, recombinant oxalate-degrading enzyme in development for the chronic management of hyperoxaluria and kidney stones (nephrolithiasis). ALLN-177 targets oxalate in the gastrointestinal tract in an effort to reduce the burden of both dietary and endogenously produced oxalate. The
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About Health Advances
Health Advances is a strategy consulting firm that focuses exclusively on the healthcare industry. The firm is composed of scientists, clinicians, and business professionals who share a passion for supporting commercialization and driving adoption of innovations that improve healthcare. The firm employs over 140 full-time professionals in four offices and has worked with over 500 companies and investors on over 2,500 assignments, across the entire spectrum of healthcare services, providing fresh perspectives, relevant knowledge, and actionable insights.
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